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Updated: Jun 13, 2026

Radioactive in situ Hybridization for Detecting Diverse Gene Expression Patterns in Tissue
Published on: April 27, 2012
NeuN/Fox-3 is an intrinsic component of the neuronal nuclear matrix
Myrna A R Dent1, Edith Segura-Anaya, Janeth Alva-Medina
1Facultad de Medicina, Universidad Autónoma del Estado de México, Toluca, México, Mexico.
Abstract:
NeuN is an antigen detected in the nucleus of neurons in a wide range of vertebrates and so it is widely used as a tool for detecting neuronal cells. NeuN has been recently identified as Fox-3, a new member of the Fox-1 gene family of splicing factors. The predominant localization of NeuN/Fox-3 to neuronal nuclei and its role in splicing pose the question of the nuclear compartmentalization of such a protein. Here we provide evidence that NeuN/Fox-3 is an intrinsic component of the neuronal nuclear matrix and a reliable marker of nuclear speckles in neurons.
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