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Sex hormone-binding globulin in osteoporosis
Emmanuel Hoppé1, Béatrice Bouvard, Matthieu Royer
1Inserm U922, service de rhumatologie, CHU, 4, rue Larrey, 49933 Angers cedex 9, France. emhoppe@chu-angers.fr
Joint Bone Spine
|May 11, 2010
Summary
Sex hormone-binding globulin (SHBG) influences bone health by regulating sex steroids. Higher SHBG levels are linked to increased fracture risk, suggesting it may predict osteoporosis severity.
Area of Science:
- Endocrinology
- Bone Biology
- Metabolic Diseases
Background:
- Sex hormone-binding globulin (SHBG) is a glycoprotein regulating sex steroid bioavailability.
- SHBG influences cellular signaling via membrane receptors (SHBG-R).
- Plasma SHBG levels are affected by various factors including age, weight, sex steroids, and insulin.
Purpose of the Study:
- To investigate the association between SHBG levels and osteoporosis.
- To determine if SHBG can predict osteoporotic fractures and bone mineral density.
Main Methods:
- Review of studies correlating serum SHBG levels with bone mineral density.
- Analysis of the relationship between SHBG and bone turnover markers.
- Evaluation of SHBG's predictive value for osteoporotic fractures.
Main Results:
- An inverse correlation exists between serum SHBG and bone mineral density in both sexes.
- SHBG levels show weaker associations with bone turnover markers.
- Elevated SHBG levels predict vertebral and peripheral osteoporotic fractures, particularly in the proximal femur.
Conclusions:
- SHBG, along with estradiol, is crucial in the development of bone loss and osteoporotic fractures.
- Serum SHBG measurement is a practical clinical tool for predicting osteoporosis severity and fracture risk.
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