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Identifying Dysregulated Genes Induced by Kaposi's Sarcoma-associated Herpesvirus (KSHV)
Published on: September 14, 2010
Kaposi sarcoma in a HIV uninfected man who has sex with men
Anja Potthoff1, N H Brockmeyer, M Stücker
1Department of Dermatology and Allergology, Ruhr-University Bochum, Gudrunstr. 56, 44791 Bochum, Germany. a.potthoff@klinikum-bochum.de
Abstract:
Kaposi's sarcoma (KS) is a rare angioproliferative tumor associated with human herpesvirus 8 (HHV-8) infection. Four clinical variants of KS have been described: classic, endemic, iatrogenic and HIV-associated. We describe a 53-year-old men who had sex with men with a rapidly growing nodule on his left foot. Histologically KS was confirmed. Our patient did not match the clinical subgroups as HIV infection or other immune disorders could be ruled out. KS in HIV-negative MSM has only been reported sporadically. It was shown that KS in these patients clinically resembles classic KS but occurs at a younger age, is limited to the skin, and is associated with a good prognosis.
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