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Updated: Jun 13, 2026

Experimental Demyelination and Remyelination of Murine Spinal Cord by Focal Injection of Lysolecithin
08:57

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Published on: March 26, 2015

Osmotic demyelination syndrome.

Joshua D King1, Mitchell H Rosner

  • 1Department of Medicine, University of Virginia Health System, Charlottesville, 22908, USA.

The American Journal of the Medical Sciences
|May 11, 2010
PubMed
Summary
This summary is machine-generated.

Osmotic demyelination syndrome (ODS) can occur from rapid correction of low serum sodium or other conditions. Brain cell dehydration and axonal damage are key features, suggesting a complex pathogenesis beyond just sodium levels.

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Area of Science:

  • Neurology
  • Cellular Biology
  • Medical Complications

Background:

  • Osmotic demyelination syndrome (ODS) is a known complication of rapid hyponatremia correction.
  • Emerging evidence links ODS to conditions unrelated to serum sodium levels.
  • This suggests a broader pathophysiological mechanism involving cellular osmolality response.

Purpose of the Study:

  • To explore the complex pathogenesis of osmotic demyelination syndrome (ODS).
  • To investigate the role of brain cell response to interstitial osmolality changes in ODS.
  • To review potential preventative strategies for ODS.

Main Methods:

  • Review of existing literature on osmotic demyelination syndrome (ODS).
  • Analysis of clinical features and neuroimaging findings in ODS patients.
  • Examination of proposed cellular mechanisms and preventative treatments.

Main Results:

  • ODS pathogenesis may involve brain cell dehydration and axonal damage due to impaired osmolality regulation.
  • Clinical presentation includes quadriparesis and neurocognitive deficits.
  • Characteristic brain MRI lesions are indicative of ODS.

Conclusions:

  • ODS pathogenesis is complex, involving cellular responses to osmolality shifts.
  • Slow correction of hyponatremia remains a primary preventive measure.
  • Reintroducing hyponatremia and corticosteroid use are potential ODS prevention strategies.