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Related Concept Videos

Elastin is Responsible for Tissue Elasticity01:12

Elastin is Responsible for Tissue Elasticity

Elastic fiber contains the protein elastin along with lesser amounts of other proteins and glycoproteins. The main property of elastin is that it will return to its original shape after being stretched or compressed. Elastic fibers are prominent in elastic tissues found in skin and the elastic ligaments of the vertebral column.
Ligaments and tendons are made of dense regular connective tissue, but in ligaments not all fibers are parallel. Dense regular elastic tissue contains elastin fibers and...
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Members Made of Elastoplastic Material

The behavior of elastoplastic materials under bending stresses, particularly in structural members with rectangular cross-sections, is crucial for predicting material responses and understanding failure modes. Initially, when a bending moment is applied, the stress distribution across the section follows Hooke's Law and is linear and elastic. This distribution means the stress increases from the neutral axis to the maximum at the outer fibers, up to the elastic limit.
As the bending moment...
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Relation between Poisson's ratio, Modulus of Elasticity and Modulus of Rigidity

Deformation occurs in axial and transverse directions when an axial load is applied to a slender bar. This deformation impacts the cubic element within the bar, transforming it into either a rectangular parallelepiped or a rhombus, contingent on its orientation. This transformation process induces shearing strain. Axial loading elicits both shearing and normal strains. Applying an axial load instigates equal normal and shearing stresses on elements oriented at a 45° angle to the load axis.
Fibrous Proteins00:55

Fibrous Proteins

Fibrous proteins are either long and narrow proteins or assemble to form long and thin structures. They contain repetitive units and usually consist of either alpha helices or beta sheets and, in rare cases, a mix of both. The amino acids in the primary structure often consist of repeating amino acid sequences. The role of fibrous proteins is primarily structural. Many are located in the extracellular matrix and are present in connective tissues to impart strength and joint mobility. They are...
Extracellular Matrix01:26

Extracellular Matrix

Unlike epithelial tissue, which is composed of cells closely packed with little or no extracellular space in between, connective tissue cells are dispersed in a matrix. This extracellular matrix (ECM) is composed of fibrous proteins like collagen, elastin, and fibronectin in a ground substance consisting of interstitial fluid, cell adhesion proteins, and proteoglycans. The proteoglycans form a gel-like material in the spaces between cells and provide hydration, buffering, binding, and force...
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Structural Protein Function

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Controlled Strain of 3D Hydrogels under Live Microscopy Imaging
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Published on: December 4, 2020

Structural disorder and dynamics of elastin.

Lisa D Muiznieks1, Anthony S Weiss, Fred W Keeley

  • 1Research Institute, Hospital for Sick Children, 555 University Ave., Toronto, ON M5G 1X8, Canada. l.muiznieks@gmail.com

Biochemistry and Cell Biology = Biochimie Et Biologie Cellulaire
|May 11, 2010
PubMed
Summary
This summary is machine-generated.

Elastin, a key protein for tissue elasticity, exhibits inherent structural disorder. This disorder drives the protein's elastic recoil, revealing it as a fundamental aspect of elastin's structure and function.

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Area of Science:

  • Biochemistry
  • Structural Biology
  • Biophysics

Background:

  • Elastin is an extracellular matrix protein crucial for tissue elasticity.
  • Its unique properties enable tissues to stretch and recoil.

Purpose of the Study:

  • To review four decades of structural studies on elastin.
  • To synthesize evidence for inherent flexibility and disorder in elastin structure.
  • To link conformational disorder to the mechanism of elastic recoil.

Main Methods:

  • Comprehensive review of structural research on elastin.
  • Analysis of evidence for solution flexibility and disorder.
  • Correlation of structural findings with functional properties.

Main Results:

  • Elastin displays conformational disorder at all structural levels.
  • This disorder is consistent across various studies.
  • Evidence supports an entropy-driven mechanism for elastic recoil.

Conclusions:

  • Conformational disorder is an intrinsic characteristic of elastin.
  • This disorder is essential for elastin's function in providing elasticity.
  • Elastin's structure and function are fundamentally linked to its disordered nature.