Intrahepatic sarcomatoid cholangiocarcinoma
Shalini Malhotra1, Joanna Wood, Talal Mansy
1Department of Histopathology, Nottingham University Hospitals, Queens Medical Centre Campus, University of Nottingham, NG7 2UH Nottingham, UK.
Abstract:
Intrahepatic sarcomatoid cholangiocarcinoma is a rare but an aggressive variant of cholangiocarcinoma with a very poor prognosis. We report the first caucasian patient who presented with a rapidly enlarging liver mass requiring hepatic resection. Detailed histopathological analyses including immunohistochemistry and electron microscopy confirmed sarcomatoid cholangiocarcinoma. The patient had early onset disease recurrence within 5 weeks of surgery. Here we demonstrate that combination chemotherapy with gemcitabine and cisplatin is a potential treatment option in patients with advanced sarcomatous cholangiocarcinoma. The patient achieved sustained partial remission with combination chemotherapy and remains alive and well more than 29 months since initial surgery.
