Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Video

Updated: Jun 13, 2026

Microfluidic Chips Controlled with Elastomeric Microvalve Arrays
18:11

Microfluidic Chips Controlled with Elastomeric Microvalve Arrays

Published on: October 1, 2007

Functional patterning of PDMS microfluidic devices using integrated chemo-masks.

Mark B Romanowsky1, Michael Heymann, Adam R Abate

  • 1School of Engineering and Applied Sciences/Department of Physics, Harvard University, Cambridge, Massachusetts, USA.

Lab on a Chip
|May 11, 2010
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Spatially resolved transcriptome-metabolome integration reveals region-specific glial lipid dysregulation associated with Alzheimer's pathology.

bioRxiv : the preprint server for biology·2026
Same author

PURE-seq integrates FACS and PIP-seq for single-cell genomics of ultra-rare cells.

Nature communications·2026
Same author

Deterministic cell pairing with simultaneous microfluidic merging and sorting of droplets.

Lab on a chip·2025
Same author

Tumor heterogeneity underlies clinical outcome and MEK inhibitor response in somatic NF1-mutant glioblastoma.

JCI insight·2025
Same author

Myeloid-mesenchymal crosstalk drives ARG1-dependent profibrotic metabolism via ornithine in lung fibrosis.

The Journal of clinical investigation·2025
Same author

Path to a 100 kHz 2D IR spectrometer based on a tunable Er fiber front end.

Optics express·2025
Same journal

Microfluidic rare cell analysis beyond counting: workflow design from enrichment to multi-omics.

Lab on a chip·2026
Same journal

A sperm racetrack to separate sperm by swim speed.

Lab on a chip·2026
Same journal

Controlled encapsulation and droplet size prediction in two-step microfluidic double emulsions.

Lab on a chip·2026
Same journal

A particulate blood-mimicking fluid with physiological biconcave geometry for microscale hemorheology.

Lab on a chip·2026
Same journal

Multicellular sensor arrays fabricated by capillary stamping for pattern-based odor discrimination.

Lab on a chip·2026
Same journal

A real-time microfluidic surveillance system for multiplex detection of heavy metal contamination in wastewater.

Lab on a chip·2026
See all related articles

This study introduces a novel chemo-masking technique for patterning polydimethylsiloxane (PDMS) microfluidic devices. This method enables precise control over surface properties for advanced applications like double emulsification.

Area of Science:

  • Materials Science
  • Microfluidics
  • Surface Chemistry

Background:

  • Polydimethylsiloxane (PDMS) microfluidic devices are widely fabricated using soft lithography.
  • The inherent softness of PDMS hinders photolithographic surface patterning, limiting applications like double emulsification.

Purpose of the Study:

  • To develop a new, effective method for patterning the surface properties of PDMS microfluidic devices.
  • To overcome the limitations of photolithography on soft PDMS surfaces.

Main Methods:

  • Fabrication of integrated oxygen reservoirs within PDMS microfluidic devices during initial molding.
  • Utilizing oxygen diffusion from these reservoirs as "chemo-masks" to inhibit localized polymer growth.
  • Controlling polymerization patterns through strategic placement of the chemo-masks.

More Related Videos

Patterning of Microorganisms and Microparticles through Sequential Capillarity-assisted Assembly
10:17

Patterning of Microorganisms and Microparticles through Sequential Capillarity-assisted Assembly

Published on: November 4, 2021

Evaluation of Cancer Stem Cell Migration Using Compartmentalizing Microfluidic Devices and Live Cell Imaging
09:36

Evaluation of Cancer Stem Cell Migration Using Compartmentalizing Microfluidic Devices and Live Cell Imaging

Published on: December 23, 2011

Related Experiment Videos

Last Updated: Jun 13, 2026

Microfluidic Chips Controlled with Elastomeric Microvalve Arrays
18:11

Microfluidic Chips Controlled with Elastomeric Microvalve Arrays

Published on: October 1, 2007

Patterning of Microorganisms and Microparticles through Sequential Capillarity-assisted Assembly
10:17

Patterning of Microorganisms and Microparticles through Sequential Capillarity-assisted Assembly

Published on: November 4, 2021

Evaluation of Cancer Stem Cell Migration Using Compartmentalizing Microfluidic Devices and Live Cell Imaging
09:36

Evaluation of Cancer Stem Cell Migration Using Compartmentalizing Microfluidic Devices and Live Cell Imaging

Published on: December 23, 2011

Main Results:

  • Demonstration of a simple and scalable method for surface patterning PDMS microfluidic devices.
  • Successful inhibition of functional polymer growth in specific channel segments via oxygen diffusion.
  • Compatibility of the chemo-masking technique with various surface chemistries.

Conclusions:

  • The developed chemo-masking technique offers a robust solution for surface patterning PDMS microfluidics.
  • This method facilitates advanced microfluidic applications requiring controlled surface properties.
  • The technique is simple, scalable, and versatile for different surface chemistries.