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Published on: January 29, 2018
Bone status in adolescents with type 1 diabetes
A P Chobot1, A Haffke, J Polanska
1Department of Paediatrics, Clinical Hospital No. 1, 3-go Maja 13-15, 41-800 Zabrze, Poland. pjarosz-chobot@sum.edu.pl
Adolescents with type 1 diabetes show poorer bone status compared to healthy peers. Long-term blood sugar control significantly impacts bone health in these young individuals.
Area of Science:
- Pediatric Endocrinology
- Metabolic Bone Disease
- Diabetes Mellitus Research
Background:
- Type 1 diabetes (T1D) can affect adolescent development.
- Assessing bone status in T1D is crucial for long-term health outcomes.
Purpose of the Study:
- To investigate the impact of type 1 diabetes on adolescent bone status.
- To analyze the influence of metabolic control and disease-related factors on bone health.
Main Methods:
- Quantitative ultrasound (QUS) used to assess bone status in 99 adolescents with T1D.
- Comparison with 297 healthy, age- and sex-matched controls.
- Analysis of glycated hemoglobin (HbA1c), diabetes duration, and daily insulin requirement (DIR).
Main Results:
- Adolescents with T1D had higher BMI SDS and lower amplitude-dependent speed of sound (Ad-SoS) SDS, indicating reduced bone status.
- No correlation found between Ad-SoS SDS and diabetes duration or DIR.
- Lower bone status was more pronounced in patients with higher long-term HbA1c (HbA1cT > 7.0%).
Conclusions:
- Adolescent bone status differs significantly in type 1 diabetes mellitus compared to healthy individuals.
- Long-term metabolic control, reflected by HbA1cT, is a key determinant of bone status in adolescents with T1D.
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