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Updated: Jun 13, 2026

Static Adhesion Assay for the Study of Integrin Activation in T Lymphocytes
Published on: June 13, 2014
Regulation of signal transduction by integrins
Y Miyamoto1, P Reddig, R L Juliano
1Department of Pharmacology, University of North Carolina, CB 7365, Chapel Hill, NC, 27599-7365, USA.
Abstract:
The integrin family of cell membrane receptors plays an important role in signal transduction cascades. Ligation of integrins by extracellular matrix proteins can lead to direct activation of Rho-family GTPases and MAP kinase pathways. However, perhaps the most significant signaling function of integrins is to modulate signal transduction events initiated by receptor tyrosine kinases and G protein-coupled receptors. This probably plays a role in coordinating information about cell shape and position with information about the availability of soluble growth factors.
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