Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Satellite Stem Cells and Muscular Dystrophy01:21

Satellite Stem Cells and Muscular Dystrophy

Satellite stem cells or myosatellite cells are quiescent stem cells that Alexander Mauro first identified in 1961. These cells are located between the sarcolemma, the plasma membrane of muscle fibers, and the basal lamina, the connective tissue sheath covering it. These mononucleated cells are activated in response to muscle injury, can transform into myoblasts, and may form or repair muscle fibers. Myosatellite cells can provide additional myonuclei for muscle regeneration or return to a...
Neurogenesis and Regeneration of Nervous Tissue01:15

Neurogenesis and Regeneration of Nervous Tissue

In the CNS, neurogenesis, the birth of new neurons from stem cells, is limited to the hippocampus in adults. In other regions of the brain and spinal cord, neurogenesis is almost non-existent due to inhibitory influences from neuroglia, especially oligodendrocytes, and the absence of growth-stimulating cues. The myelin produced by oligodendrocytes in the CNS inhibits neuronal regeneration. Furthermore, astrocytes proliferate rapidly after neuronal damage, forming scar tissue that physically...
iPS Cell Differentiation01:22

iPS Cell Differentiation

The ability of induced pluripotent stem cells or iPSCs to differentiate into most body cell types has stimulated repair and regenerative medicine research over the past few decades. iPSC-derived blood cells, hepatocytes, beta islet cells, cardiomyocytes, neurons, and other cell types can repair injuries or regenerate damaged tissue in diseases such as diabetes and neurodegenerative disorders.
Nervous Tissue: Myelin01:25

Nervous Tissue: Myelin

The myelin sheath is a multilayered lipid and protein covering that insulates the axon of a neuron, enhancing the speed of nerve impulse conduction. Axons without this sheath are referred to as unmyelinated. Two types of neuroglia, Schwann cells in the peripheral nervous system (PNS) and oligodendrocytes in the central nervous system (CNS) are responsible for producing myelin sheaths.
Schwann cells begin to form myelin sheaths around axons during fetal development. They wrap around a small...
EPS and iPS Cells in Disease Research01:21

EPS and iPS Cells in Disease Research

Embryonic and induced pluripotent stem cells are excellent models for disease research because of their ability to self-renew and differentiate into most cell types. Somatic cells from a patient are isolated and reprogrammed into induced pluripotent stem cells or iPSCs. These iPSCs are later differentiated into the desired cell type, which mirrors the diseased cell of the patient. In this way, disease models have been created for investigating diseases such as Down syndrome, type I diabetes,...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A service evaluation of the recognition, care and management of functional seizures within a UK ambulance service.

British paramedic journal·2026
Same author

Geo-Mapping Using In-Hospital Massive Transfusion Data as a Method for Prehospital Blood Management for Trauma Patients.

Journal of the American College of Surgeons·2026
Same author

Encephalitic rabies following cat bites: two cases in northern Uganda.

Practical neurology·2026
Same author

Primary central nervous system vasculitis: an update.

Journal of neurology·2026
Same author

Profiling peripheral blood oxidative stress in multiple sclerosis.

Multiple sclerosis and related disorders·2026
Same author

Development of a diagnostic checklist to identify functional cognitive disorder versus other neurocognitive disorders.

BMJ neurology open·2025

Related Experiment Video

Updated: Jun 13, 2026

Comprehensive Autopsy Program for Individuals with Multiple Sclerosis
09:41

Comprehensive Autopsy Program for Individuals with Multiple Sclerosis

Published on: July 19, 2019

Stem cells in genetic myelin disorders.

Kevin Kemp1, Elizabeth Mallam, Neil Scolding

  • 1MS & Stem Cell Laboratories, Burden Centre, Frenchay Hospital, Bristol, UK.

Regenerative Medicine
|May 12, 2010
PubMed
Summary

Stem cells show promise for treating genetic myelin disorders by restoring myelin and offering broader therapeutic benefits. Research reviews stem cell applications and transplantation studies for these severe neurological conditions.

More Related Videos

Preparation of Rat Oligodendrocyte Progenitor Cultures and Quantification of Oligodendrogenesis Using Dual-infrared Fluorescence Scanning
11:11

Preparation of Rat Oligodendrocyte Progenitor Cultures and Quantification of Oligodendrogenesis Using Dual-infrared Fluorescence Scanning

Published on: February 17, 2016

Related Experiment Videos

Last Updated: Jun 13, 2026

Comprehensive Autopsy Program for Individuals with Multiple Sclerosis
09:41

Comprehensive Autopsy Program for Individuals with Multiple Sclerosis

Published on: July 19, 2019

Preparation of Rat Oligodendrocyte Progenitor Cultures and Quantification of Oligodendrogenesis Using Dual-infrared Fluorescence Scanning
11:11

Preparation of Rat Oligodendrocyte Progenitor Cultures and Quantification of Oligodendrogenesis Using Dual-infrared Fluorescence Scanning

Published on: February 17, 2016

Area of Science:

  • Neuroscience
  • Genetics
  • Regenerative Medicine

Background:

  • Genetic myelin disorders cause severe neurological deficits from infancy.
  • Current therapies are limited, highlighting the need for novel treatments.
  • Stem cells are investigated for their potential to restore myelin and provide broader therapeutic effects.

Purpose of the Study:

  • To review common genetic myelin disorders and existing therapies.
  • To explore the potential of stem cells as a therapeutic strategy.
  • To discuss stem cell subtypes and their application in animal models.

Main Methods:

  • Literature review of genetic myelin disorders and current treatments.
  • Analysis of stem cell potential for myelin repair, enzyme/gene replacement, and trophic support.
  • Review of stem cell transplantation studies in animal models.

Main Results:

  • Stem cells offer potential beyond myelin restoration, including gene therapy and neuroprotection.
  • Bone marrow transplantation is a current therapy for specific disorders like adrenoleukodystrophy.
  • Animal studies demonstrate the feasibility and efficacy of stem cell transplantation.

Conclusions:

  • Stem cell therapy holds significant promise for treating genetic myelin disorders.
  • Further research into specific stem cell subtypes and transplantation is warranted.
  • Stem cells represent a potential paradigm shift in managing these debilitating neurological conditions.