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Related Experiment Video

Updated: Jun 13, 2026

Modeling Neural Immune Signaling of Episodic and Chronic Migraine Using Spreading Depression In Vitro

Modeling Neural Immune Signaling of Episodic and Chronic Migraine Using Spreading Depression In Vitro

Published on: June 13, 2011

Cortical spreading depression triggers migraine attack: pro.

¹Neurovascular Research Laboratory, Department of Radiology, and Stroke Service, Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.

|May 12, 2010

Summary

This summary is machine-generated.

Spreading depression (SD) is an electrophysiological phenomenon linked to migraine aura. Emerging evidence supports its causal role in migraine headache, even in attacks without perceived aura.

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Last Updated: Jun 13, 2026

Modeling Neural Immune Signaling of Episodic and Chronic Migraine Using Spreading Depression In Vitro

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Published on: June 2, 2014

Area of Science:

Neuroscience
Electrophysiology

Background:

Spreading depression (SD) was first described over 60 years ago as a transient depression of electrocorticographic activity.
SD is an evolutionarily preserved intrinsic electrophysiological property of central nervous systems.

Purpose of the Study:

To review evidence supporting a causal relationship between SD and migraine aura and headache.
To discuss the potential role of SD in migraine attacks lacking perceived aura.

Main Methods:

Review of clinical and experimental studies.
Analysis of electrophysiological and symptomatological data.

Main Results:

Similarities between migraine aura symptoms and SD electrophysiological features suggest a link.
Recent clinical and experimental evidence strengthens the SD theory of migraine.
The role of SD in migraines without aura is under investigation.

Conclusions:

Accumulated evidence supports a causal relationship between spreading depression and migraine aura.
Spreading depression may also contribute to migraine attacks experienced without a "perceived" aura.