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Postprandial lipaemia, oxidative stress and endothelial function: a review
J P Wallace1, B Johnson, J Padilla
1Clinical Exercise Physiology Laboratory, Department of Kinesiology, Indiana University, Bloomington, IN 47405, USA. wallacej@indiana.edu
International Journal of Clinical Practice
|May 12, 2010
Summary
Postprandial lipaemia, a state after eating, can impair endothelial function, potentially through oxidative stress. While links between lipaemia and oxidative stress are strong, the connection between oxidative stress and endothelial function needs better measurement methods.
Area of Science:
- Cardiovascular Research
- Metabolic Studies
- Biomarker Analysis
Background:
- Postprandial lipaemia is implicated in endothelial dysfunction.
- Oxidative stress is hypothesized as a key mediator.
- Understanding these relationships is crucial for cardiovascular health.
Purpose of the Study:
- To review cross-sectional studies examining relationships between postprandial lipaemia, oxidative stress, and endothelial function.
- To evaluate the strength and consistency of associations among these variables.
- To identify limitations in current measurement techniques.
Main Methods:
- Medline search (1980-2008) identified 20 relevant human studies.
- Studies required reporting correlations between at least two of the three variables.
- Review focused on biomarkers, reported associations, and other considerations.
Main Results:
- Triglycerides and free fatty acids are reliable biomarkers for lipaemia.
- Oxidative stress measures lack standardization.
- Strong associations exist between lipaemia and oxidative stress, and lipaemia and endothelial function.
- The link between oxidative stress and endothelial function appears weak with current methods.
Conclusions:
- Findings support the hypothesis that oxidative stress mediates adverse effects of postprandial lipaemia on endothelial function.
- Current measurement challenges for oxidative stress limit definitive conclusions.
- Standardizing oxidative stress measurement is essential for future research.
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