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Hypothalamic-midbrain dysregulation syndrome: hypertension, hyperthermia, hyperventilation, and decerebration
M R Pranzatelli1, S G Pavlakis, R J Gould
1Department of Neurology, Columbia University, New York.
Journal of Child Neurology
|April 1, 1991
Summary
This study identifies a novel clinical syndrome in children recovering from coma, characterized by hypothalamic-mesencephalic dysfunction leading to reversible hypertension and hyperthermia. Propranolol showed potential therapeutic benefits in some patients.
Area of Science:
- Neuroscience
- Pediatric Neurology
- Clinical Medicine
Background:
- Brain stem and hypothalamic lesions in animals can cause reversible hypertension and hyperthermia.
- Understanding these mechanisms is crucial for managing complex neurological conditions in children.