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Does indomethacin for closure of patent ductus arteriosus affect cerebral function?
A Flisberg1, I Kjellmer, J Löfhede
1Department of Pediatrics, The Queen Silvia Children's Hospital Sahlgrenska University Hospital-Östra, Göteborg, Sweden. anders.flisberg@vgregion.se
Objective:
To study whether indomethacin used in conventional dose for closure of patent ductus arteriosus affects cerebral function measured by electroencephalograms (EEG) evaluated by quantitative measures.
Study Design:
Seven premature neonates with haemodynamically significant persistent ductus arteriosus were recruited. EEG were recorded before, during and after an intravenous infusion of 0.2 mg/kg indomethacin over 10 min. The EEG was analysed by two methods with different degrees of complexity for the amount of low-activity periods (LAP, "suppressions") as an indicator of affection of cerebral function.
Results:
Neither of the two methods identified any change in the amount of LAPs in the EEG as compared to before the indomethacin infusion.
Conclusion:
Indomethacin in conventional dose for closure of patent ductus arteriosus does not affect cerebral function as evaluated by quantitative EEG.
