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Handgrip contraction induces a linear increase in arterial pressure by peripheral vasoconstriction, increased heart

K Toska1

  • 1Department of Physiology, Institute of Basic Medical Sciences, University of Oslo, Oslo, Norway. ktoska@medisin.uio.no

Acta Physiologica (Oxford, England)
|May 12, 2010
PubMed
Summary
This summary is machine-generated.

Isometric handgrip exercise increases mean arterial pressure by raising the arterial baroreflex set point. This response effectively regulates blood pressure during dynamic exercise, demonstrating baroreflex adaptation.

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10:48

Assessing Myogenic Response and Vasoactivity In Resistance Mesenteric Arteries Using Pressure Myography

Published on: July 6, 2015

Area of Science:

  • Cardiovascular Physiology
  • Exercise Physiology
  • Autonomic Nervous System Regulation

Background:

  • Isometric handgrip exercise is known to elevate arterial pressure.
  • The precise mechanisms, particularly the role of baroreflex control, require further elucidation.

Purpose of the Study:

  • To test the hypothesis that isometric handgrip exercise causes a progressive increase in arterial pressure.
  • To investigate if this increase is associated with a linear rise in the arterial pressure control setpoint.

Main Methods:

  • Continuous monitoring of heart rate, stroke volume, and mean arterial pressure during 2-minute isometric handgrip at 40% maximal voluntary contraction.
  • Induction of transient arterial pressure changes via thigh cuff inflation/deflation to assess baroreflex responses.

Main Results:

  • Isometric handgrip led to increased heart rate, decreased stroke volume, and a slight increase in cardiac output, with increased total peripheral conductance.
  • Baroreflex responses effectively restored arterial pressure to the rising trajectory following induced pressure perturbations.

Conclusions:

  • The arterial pressure increase during isometric handgrip is attributed to a rising arterial baroreflex setpoint.
  • Baroreflex sensitivity and response kinetics remain largely unchanged during this process.