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Systematic review: fatigue in inflammatory bowel disease
D R van Langenberg1, P R Gibson
1Monash University Department of Gastroenterology & Hepatology, Medicine, Box Hill Hospital, Box Hill, Melbourne, Vic., Australia. Daniel.van-Langenberg@med.monash.edu.au
Alimentary Pharmacology & Therapeutics
|May 12, 2010
Summary
Fatigue significantly impacts patients with inflammatory bowel disease (IBD), yet research is limited. More studies are needed to understand fatigue prevalence and its connection to disease activity in IBD.
Area of Science:
- Gastroenterology
- Immunology
- Chronic Disease Management
Background:
- Fatigue is a prevalent and debilitating symptom in patients with chronic diseases, notably inflammatory bowel disease (IBD).
- Despite its impact, fatigue in IBD remains underappreciated and inadequately researched.
Purpose of the Study:
- To systematically review existing literature on the prevalence and patterns of fatigue in IBD patients.
- To identify gaps in current research and suggest future directions for investigating fatigue in IBD.
Main Methods:
- A systematic literature review was conducted using PubMed and Ovid Medline databases.
- Search terms included 'fatigue', 'Crohn's disease', 'ulcerative colitis', and 'inflammatory bowel disease'.
- A comparative review of fatigue in other chronic diseases was also performed.
Main Results:
- Ten studies published between 1999 and 2009 contained data on fatigue in IBD patients.
- Only one study focused on fatigue as a primary outcome, specifically in pediatric IBD patients.
- Fatigue prevalence in IBD patients in remission ranged from 41% to 48%.
Conclusions:
- There is a paucity of research examining fatigue as a primary outcome in IBD.
- Further investigation is required to establish the prevalence of fatigue, its correlation with disease activity, and its pathogenic mechanisms in IBD.
- Elucidating these factors is crucial for developing targeted therapies for fatigue in IBD patients.
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