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Mohs' micrographic surgery for dermatofibrosarcoma protuberans
1Department of Dermatology and Cutaneous Biology Research Institute, Yonsei University College of Medicine, Seoul, Korea.
Clinical and Experimental Dermatology
|May 12, 2010
Summary
Mohs micrographic surgery (MMS) offers a low recurrence rate for dermatofibrosarcoma protuberans (DFSP), a rare soft-tissue tumor. This approach may also result in smaller surgical defects compared to traditional wide local excision.
Area of Science:
- Oncology
- Dermatology
- Surgical Pathology
Background:
- Dermatofibrosarcoma protuberans (DFSP) is a rare soft-tissue neoplasm.
- DFSP is characterized by a high rate of local recurrence.
- Mohs micrographic surgery (MMS) shows promise for improved DFSP cure rates.
Purpose of the Study:
- To evaluate the efficacy of MMS for treating DFSP.
- To assess recurrence rates of DFSP treated with MMS in a Korean single-institution cohort.
- To compare MMS outcomes with other DFSP treatment modalities.
Main Methods:
- Retrospective chart review of 11 DFSP patients treated between 1997 and 2007.
- Analysis of demographic, tumor, treatment, and follow-up data.
- Literature review of DFSP treatment methods and recurrence rates.
Main Results:
- Eleven DFSP cases (7 female, 4 male; mean age 26.9 years) were analyzed.
- Complete tumor clearance required an average of 1.8 MMS layers.
- No recurrences were observed during an average follow-up of 26 months.
Conclusions:
- MMS treatment for DFSP, both primary and recurrent, yields a low recurrence rate.
- MMS may offer the advantage of smaller surgical defects compared to wide local excision.
- MMS is supported as a preferred treatment option for dermatofibrosarcoma protuberans.
