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X-Ray Visualization of Intraductal Ethanol-Based Ablative Treatment for Prevention of Breast Cancer in Rat Models

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Prolactin and human tumourogenesis.

I Fernandez¹, P Touraine, V Goffin

¹Inserm, Unit 845, Research Center Growth and Signalling, University Paris Descartes, Faculty of Medicine, Necker site, Paris, France.

Journal of Neuroendocrinology

|May 12, 2010

Summary

Prolactin

Area of Science:

Endocrinology
Oncology
Molecular Biology

Background:

The role of prolactin in human tumourogenesis remains debated.
Previous studies in the 1980s yielded inconclusive results in human species.
Rodent models provided early evidence for prolactin's role in breast cancer.

Purpose of the Study:

To discuss recent advancements in understanding prolactin's nonclassical mechanisms in tumor growth.
To explore the potential of targeting prolactin signaling in future cancer therapies.
To review novel actions of prolactin in breast cancer cells.

Main Methods:

Review of recent scientific literature on prolactin and tumourogenesis.
Analysis of data from genetically-modified mouse models.

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Examination of genetic variants of the prolactin receptor.

Main Results:

Two novel mechanisms of prolactin action in tumor growth have emerged: autocrine/paracrine prolactin production and constitutively active prolactin receptor variants.
Genetically-modified models show prolactin's tumorigenic potential in prostate and mammary glands.
A prolactin receptor variant with constitutive activity identified in breast tumor patients suggests sustained signaling in tumourogenesis.

Conclusions:

Local prolactin production and prolactin receptor variants represent key nonclassical mechanisms in tumourogenesis.
These findings open new avenues for inhibiting prolactin signaling in cancer therapy.
Further research is needed to develop targeted therapies against prolactin receptor signaling.