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Updated: Jun 13, 2026

Determination of Reproductive Competence by Confirming Pubertal Onset and Performing a Fertility Assay in Mice and Rats
Published on: October 13, 2018
Neurokinin B signalling in human puberty
A K Topaloglu1, L D Kotan, B Yuksel
1Faculty of Medicine, Department of Pediatric Endocrinology and Metabolism, Cukurova University, Balcali, Adana, Turkey. ktopaloglu@cu.edu.tr
Abstract:
Recent identification of TAC3 or TACR3 (encoding neurokinin B and its receptor, NK3R, respectively) mutations as the causes of normosmic idiopathic hypogonadotrophic hypogonadism has provided compelling evidence for the involvement of neurokinin B (NKB) signalling in puberty. A surge of subsequent studies pointing towards an understanding of the exact mechanism through which NKB signalling exerts its effects in puberty led to a postulated sketch of the GnRH pulse generator, in which kisspeptin, NKB and dynorphin work in concert to elicit pulsatile gonadotrophin-releasing hormone release in the median eminence.
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