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Signs of Puberty01:27

Signs of Puberty

Puberty is a critical phase, typically beginning between the ages of 8 and 13 in girls and 9 and 14 in boys, though timing can vary based on genetics, environmental factors, and overall health. This period is characterized by the development of secondary sexual characteristics and the attainment of reproductive potential. Endocrine changes underpin puberty, with hormonal surges of Luteinizing Hormone (LH) and Follicle-Stimulating Hormone (FSH) instigated by Gonadotropin-Releasing Hormone (GnRH)...
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Regulation of Hormone Secretion

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Hedgehog Signaling Pathway02:33

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Related Experiment Video

Updated: Jun 13, 2026

Determination of Reproductive Competence by Confirming Pubertal Onset and Performing a Fertility Assay in Mice and Rats
06:38

Determination of Reproductive Competence by Confirming Pubertal Onset and Performing a Fertility Assay in Mice and Rats

Published on: October 13, 2018

Neurokinin B signalling in human puberty.

A K Topaloglu1, L D Kotan, B Yuksel

  • 1Faculty of Medicine, Department of Pediatric Endocrinology and Metabolism, Cukurova University, Balcali, Adana, Turkey. ktopaloglu@cu.edu.tr

Journal of Neuroendocrinology
|May 12, 2010
PubMed
Summary

Mutations in neurokinin B (NKB) signaling pathways cause hypogonadotropic hypogonadism, revealing NKB

Area of Science:

  • Neuroendocrinology
  • Reproductive biology
  • Genetics

Background:

  • Mutations in TAC3/TACR3 (neurokinin B/neurokinin 3 receptor) cause normosmic idiopathic hypogonadotropic hypogonadism.
  • This highlights the critical role of neurokinin B (NKB) signaling in human puberty.
  • NKB is implicated in the regulation of gonadotropin-releasing hormone (GnRH) secretion.

Purpose of the Study:

  • To elucidate the precise mechanisms of NKB signaling in pubertal development.
  • To understand the interaction of NKB with other key signaling pathways in the GnRH pulse generator.

Main Methods:

  • Genetic analysis of patients with hypogonadotropic hypogonadism.
  • Molecular biology techniques to study NKB receptor interactions.
  • In vivo and in vitro studies on the GnRH neurosecretory system.

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Last Updated: Jun 13, 2026

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06:38

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Published on: October 13, 2018

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08:56

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Main Results:

  • Confirmed the causative role of TAC3/TACR3 mutations in hypogonadotropic hypogonadism.
  • Demonstrated that NKB signaling is essential for initiating GnRH pulsatility.
  • Proposed a model of the GnRH pulse generator involving kisspeptin, NKB, and dynorphin.

Conclusions:

  • Neurokinin B signaling is indispensable for normal pubertal onset.
  • NKB acts in concert with kisspeptin and dynorphin to regulate pulsatile GnRH release.
  • Understanding NKB pathways offers potential therapeutic targets for reproductive disorders.