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Related Experiment Video

Updated: Jun 13, 2026

Microfluidic Flow Chambers Using Reconstituted Blood to Model Hemostasis and Platelet Transfusion In Vitro

Microfluidic Flow Chambers Using Reconstituted Blood to Model Hemostasis and Platelet Transfusion In Vitro

Published on: March 19, 2016

Transfused stored platelets have the same haemostatic function as circulating native platelets.

W W H Roeloffzen¹, H C Kluin-Nelemans, N J G M Veeger

¹Department of Hematology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.

|May 12, 2010

Summary

This summary is machine-generated.

Transfused platelets (PLTs) show similar hemostatic function to native PLTs, but fresher platelet concentrates (PCs) offer better results. Thrombelastography (TEG) can monitor these effects, though more research is needed for clinical application.

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Last Updated: Jun 13, 2026

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Published on: March 19, 2016

Microfluidics in Assessing Platelet Function

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A Microfluidic Flow Chamber Model for Platelet Transfusion and Hemostasis Measures Platelet Deposition and Fibrin Formation in Real-time

A Microfluidic Flow Chamber Model for Platelet Transfusion and Hemostasis Measures Platelet Deposition and Fibrin Formation in Real-time

Published on: February 14, 2017

Area of Science:

Hematology
Transfusion Medicine
Hemostasis and Thrombosis

Background:

Thrombelastography (TEG) assesses whole blood hemostasis.
Platelet (PLT) transfusions are critical in managing thrombocytopenia.
The hemostatic function of transfused PLTs and the impact of storage time are not fully understood.

Purpose of the Study:

To compare the hemostatic function of transfused platelets (PLTs) with native circulating PLTs using TEG.
To evaluate the effect of storage duration on the hemostatic potential of platelet concentrates (PCs).

Main Methods:

Serial TEG measurements in 92 patients undergoing chemotherapy with decreasing PLT counts.
Comparison of TEG parameters between native PLTs and transfused PLTs during thrombocytopenia.
Comparative analysis of hemostatic potential between fresh (1-3 days) and longer-stored (4-5 days) PCs.

Main Results:

No significant difference in hemostatic potential was observed between native and transfused stored PLTs (P >= 0.1).
Fresh PLTs demonstrated superior hemostatic effects compared to longer-stored PLTs one hour post-transfusion.
Key TEG parameters (K-time and alpha angle) indicated better hemostatic capacity for fresh PCs.

Conclusions:

TEG can effectively monitor the hemostatic effects of PLT transfusions.
Transfused stored PLTs exhibit comparable hemostatic properties to native circulating PLTs.
Shorter storage times for PCs are associated with enhanced hemostatic capacity, warranting further clinical outcome research.