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An Intestine/Liver Microphysiological System for Drug Pharmacokinetic and Toxicological Assessment
Published on: December 3, 2020
The two faces of pharmacokinetics.
1rescigno@mac.com
Summary
This opinion article explores two modeling approaches in pharmacokinetics: bottom-up and top-down. It highlights the advantages of each method for building pharmacokinetic models.
Area of Science:
- Pharmacokinetics
- Mathematical Modeling
Background:
- Mathematics and Physics utilize distinct theoretical approaches.
- Pharmacokinetics can also be modeled using contrasting methodologies.
Purpose of the Study:
- To present the advantages of two opposing pharmacokinetic modeling approaches.
- To illustrate these approaches with practical examples.
Main Methods:
- Discussing the bottom-up modeling perspective.
- Discussing the top-down modeling perspective.
Main Results:
- The bottom-up approach offers detailed mechanistic insights.
- The top-down approach provides a more empirical and data-driven overview.
Conclusions:
- Both bottom-up and top-down modeling strategies have unique strengths.
- The choice of approach depends on the specific research question and available data.
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