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Fecal Glucocorticoid Analysis: Non-invasive Adrenal Monitoring in Equids
08:02

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Published on: April 25, 2016

Sub-maximal exercise altered the prednisolone absorption pattern.

Kuei-Yu Chien1, Ting-Ting Chen, Jia Hsu

  • 1Department of Geriatric Health Promotion, Kainan University, Taoyuan, Taiwan.

Journal of Pharmacy & Pharmaceutical Sciences : a Publication of the Canadian Society for Pharmaceutical Sciences, Societe Canadienne Des Sciences Pharmaceutiques
|May 12, 2010
PubMed
Summary
This summary is machine-generated.

Sub-maximal exercise significantly lowered peak prednisolone concentration but did not affect its overall exposure. Exercise increased cortisol levels, suggesting altered prednisolone absorption patterns.

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Conducting Maximal and Submaximal Endurance Exercise Testing to Measure Physiological and Biological Responses to Acute Exercise in Humans
07:26

Conducting Maximal and Submaximal Endurance Exercise Testing to Measure Physiological and Biological Responses to Acute Exercise in Humans

Published on: October 17, 2018

Area of Science:

  • Pharmacology
  • Exercise Physiology
  • Endocrinology

Background:

  • Prednisolone is a widely used corticosteroid with moderate potency and short pituitary inhibition.
  • Exercise is a key non-pharmacological strategy for preventing glucocorticoid-induced osteoporosis.
  • The impact of exercise on prednisolone pharmacokinetics remains unclear.

Purpose of the Study:

  • To investigate the effects of sub-maximal exercise on the pharmacokinetic profile of prednisolone.
  • To assess how exercise influences prednisolone absorption and elimination.
  • To evaluate the relationship between exercise and prednisolone's impact on cortisol levels.

Main Methods:

  • A randomized, double-blind, cross-over study design involving exercise and non-exercise trials.
  • Participants consumed 5 mg of prednisolone, followed by either cycling at 70% VO2max or resting.
  • Serial blood samples were collected over 12 hours, with prednisolone and cortisol concentrations analyzed via HPLC.

Main Results:

  • Sub-maximal exercise significantly reduced the maximum plasma concentration of prednisolone compared to the non-exercise trial (p<.05).
  • No significant differences were observed in area under the curve, half-life, clearance, or volume of distribution between trials.
  • The exercise trial showed a significantly higher mean percentage change in cortisol compared to the non-exercise trial (p<.05).

Conclusions:

  • Sub-maximal exercise appears to alter the absorption pattern of prednisolone.
  • Exercise may influence the rate of prednisolone absorption, leading to lower peak concentrations.
  • The findings suggest a potential interaction between exercise and prednisolone pharmacokinetics, impacting endogenous cortisol.