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DNA as a Genetic Template

DNA as a Genetic Template

Two structural features of the DNA molecule provide a basis for the mechanisms of heredity: the four nucleotide bases and its double-stranded nature. The Watson-Crick model of double-helical DNA structure, proposed in 1952, drew heavily upon the X-ray crystallography work of researchers Rosalind Franklin and Maurice Wilkins. Watson, Crick, and Wilkins jointly received the Nobel Prize in Physiology or Medicine for their work in 1962. Franklin was, controversially, excluded from the prize for...

DNA as a Genetic Template

DNA as a Genetic Template

Two structural features of the DNA molecule provide a basis for the mechanisms of heredity: the four nucleotide bases and its double-stranded nature. The Watson-Crick model of double-helical DNA structure, proposed in 1952, drew heavily upon the X-ray crystallography work of researchers Rosalind Franklin and Maurice Wilkins. Watson, Crick, and Wilkins jointly received the Nobel Prize in Physiology or Medicine for their work in 1962. Franklin was, controversially, excluded from the prize for...

The DNA Helix

The DNA Helix

Deoxyribonucleic acid, or DNA, is the genetic material responsible for passing traits from generation to generation in all organisms and most viruses. DNA is composed of two strands of nucleotides that wind around each other to form a spring-like structure called a double helix. However, the double helix is not perfectly symmetrical. Instead, there are regularly occurring grooves in the structure. The major groove occurs where the sugar-phosphate backbones are relatively far apart. This space...

The DNA Helix

The DNA Helix

The DNA Helix

The DNA Helix

DNA Topoisomerases

DNA Topoisomerases

Topoisomerases are enzymes that relax overwound DNA molecules during various cell processes, including DNA replication and transcription. These enzymes regulate positive and negative DNA supercoiling without changing the nucleotide sequence. DNA overwinding in a clockwise direction results in positively supercoiled DNA, whereas underwinding in a counterclockwise direction produces negatively supercoiled DNA.
Types and Mechanism of action
Topoisomerases are divided into two main types. Type I...

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Related Experiment Video

Updated: Jun 13, 2026

Self-assembly of Complex Two-dimensional Shapes from Single-stranded DNA Tiles

Self-assembly of Complex Two-dimensional Shapes from Single-stranded DNA Tiles

Published on: May 8, 2015

Knitting complex weaves with DNA origami.

William M Shih¹, Chenxiang Lin

¹Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA 02115, USA. William_Shih@dfci.harvard.edu

Current Opinion in Structural Biology

|May 12, 2010

Summary

This summary is machine-generated.

Researchers are using DNA branched junctions for programmable self-assembly of nanostructures. The DNA-origami method enables rapid design and creation of complex DNA nanostructures, similar in mass to small viruses.

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DNA Origami-Mediated Substrate Nanopatterning of Inorganic Structures for Sensing Applications

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Related Experiment Videos

Last Updated: Jun 13, 2026

Self-assembly of Complex Two-dimensional Shapes from Single-stranded DNA Tiles

Self-assembly of Complex Two-dimensional Shapes from Single-stranded DNA Tiles

Published on: May 8, 2015

Production of Dynein and Kinesin Motor Ensembles on DNA Origami Nanostructures for Single Molecule Observation

Production of Dynein and Kinesin Motor Ensembles on DNA Origami Nanostructures for Single Molecule Observation

Published on: October 15, 2019

DNA Origami-Mediated Substrate Nanopatterning of Inorganic Structures for Sensing Applications

DNA Origami-Mediated Substrate Nanopatterning of Inorganic Structures for Sensing Applications

Published on: September 27, 2019

Area of Science:

Biotechnology and Nanotechnology
Supramolecular Chemistry

Background:

DNA branched junctions are versatile building blocks for supramolecular assembly.
Advancements in DNA synthesis and manipulation have enabled complex nanostructure design.

Purpose of the Study:

To highlight the progress in harnessing DNA branched junctions for programmable self-assembly.
To emphasize the impact of the DNA-origami method on nanostructure fabrication.

Main Methods:

Utilizing long DNA sequences as templates for nanostructure formation.
Employing DNA-origami techniques for precise molecular assembly.

Main Results:

Demonstration of rapid prototyping of custom-shaped 2D and 3D nanostructures.
Achieved nanostructures with mass comparable to small viruses.

Conclusions:

The DNA-origami method significantly advances the field of DNA-based nanostructure self-assembly.
Complex nanostructures can now be designed, assembled, and characterized efficiently within weeks.