[Treatment and prognosis of pT2 endometrial carcinoma]

Between January, 1966 and December, 1988, 66 patients with surgical-pathological stage II adenocarcinoma of the endometrium who were treated with abdominal simple or radical hysterectomy at the Osaka National Hospital were studied retrospectively. The 5-year survival rate for all patients was 75.7%. In 33 patients adenocarcinoma had invaded the cervical stroma. These patients demonstrated a significantly lower survival (60.0%) than those patients whose involvement was limited to the endocervical gland (91.7%) (p less than 0.05). For all patients, both with endocervical glandular involvement and cervical stromal invasion, radical hysterectomy improved survival rates more than did simple hysterectomy, but the difference was not statistically significant. The factor found to have a significant influence on survival was the maximal depth of invasion of the myometrium (p less than 0.05). The histologic grade, on the other hand, did not appear to influence survival. It is suggested that patients with minimal involvement of the cervix can be satisfactorily treated with simple hysterectomy, while patients with gross cervical spread should be treated with radical hysterectomy.