Related Experiment Video

Updated: Jun 13, 2026

Optimized Management of Endovascular Treatment for Acute Ischemic Stroke
09:21

Optimized Management of Endovascular Treatment for Acute Ischemic Stroke

Published on: January 18, 2018

Current endovascular treatment of acute stroke and future aspects

Monika Killer1, Gunther Ladurner, Alexander B Kunz

  • 1Christian Doppler University Clinic Salzburg, Ignaz Harrer Strasse 79, 5020 Salzburg, Austria. m.killer@salk.at

Drug Discovery Today
|May 12, 2010
PubMed

Insights

Acute ischemic stroke treatment has expanded beyond intravenous tissue-type plasminogen activator (tPA) to include interventional therapies. New pharmacological and mechanical options offer improved outcomes for stroke patients.

Area of Science:

  • Neurology
  • Cardiovascular Medicine
  • Emergency Medicine

Background:

  • Acute ischemic stroke is a leading cause of death and disability.
  • Intravenous tissue-type plasminogen activator (tPA) is the primary established therapy.
  • Limited patient eligibility and a narrow treatment window restrict tPA use.

Purpose of the Study:

  • To review the evolution of acute ischemic stroke treatment.
  • To highlight the extended time window for IV tPA based on ECASS III data.
  • To introduce emerging interventional, pharmacological, and mechanical therapies.

Main Methods:

  • Analysis of data from the European Collaborative Acute Stroke Study (ECASS III).
  • Review of current interventional stroke therapies.
  • Discussion of novel pharmacological and mechanical treatment options.

Main Results:

  • The time window for IV tPA treatment was extended to 4.5 hours post-stroke symptom onset.
  • Interventional stroke therapies are crucial for patients outside the extended IV tPA window.
  • New treatment strategies are being integrated into routine clinical practice.

Conclusions:

  • Treatment options for acute ischemic stroke have significantly advanced.
  • Extended IV tPA timelines and interventional therapies improve patient outcomes.
  • Ongoing research and development promise further advancements in stroke care.

More Related Videos

Reduction of Radiation Exposure during Endovascular Treatment of Peripheral Arterial Disease Combining Fiber Optic RealShape Technology and Intravascular Ultrasound13:48

Reduction of Radiation Exposure during Endovascular Treatment of Peripheral Arterial Disease Combining Fiber Optic RealShape Technology and Intravascular Ultrasound

Published on: April 21, 2023

Related Concept Videos

Venous Thrombosis III: Interprofessional Care01:29

Venous Thrombosis III: Interprofessional Care

Venous thrombosis requires effective prevention and treatment strategies to improve patient outcomes and reduce potential complications.Prevention StrategiesHealthcare providers must prioritize preventing venous thromboembolism (VTE) for all adult patients upon admission. Interventions depend on bleeding and thrombosis risk, medical history, current medications, diagnoses, planned procedures, and patient preferences. Patients on bed rest should change positions every two hours and, if not...
Ischemic Stroke l: Introduction01:15

Ischemic Stroke l: Introduction

Ischemic stroke is an acute cerebrovascular condition in which blood flow to a brain region is suddenly interrupted, leading to tissue infarction. Neurons depend on continuous oxygen and glucose supply, so even brief reductions in perfusion cause energy failure, ionic imbalance, and irreversible injury. Ischemic strokes are classified into thrombotic and embolic types based on their underlying mechanisms.Thrombotic MechanismsThrombotic stroke develops when a clot forms within a cerebral artery.
Ischemic Stroke ll: Pathophysiology01:15

Ischemic Stroke ll: Pathophysiology

An ischemic stroke occurs when a cerebral blood vessel becomes obstructed, most often by a thrombus or embolus, interrupting the delivery of oxygen and glucose to brain tissue. Because neurons rely on continuous aerobic metabolism, energy failure begins within minutes of reduced perfusion. The region receiving the least blood flow becomes the infarct core, an area of irreversible cellular death. Surrounding this core lies the penumbra, a zone of hypoperfused but still viable tissue that is...
Hemorrhagic Stroke ll: Pathophysiology01:29

Hemorrhagic Stroke ll: Pathophysiology

A hemorrhagic stroke develops when a cerebral blood vessel ruptures, allowing blood to escape into the surrounding brain tissue, as in intracerebral hemorrhage (ICH), or into the subarachnoid space, as in subarachnoid hemorrhage (SAH). Because the skull is a rigid compartment, the sudden presence of extravascular blood rapidly increases intracranial pressure and compresses adjacent neural structures, leading to immediate tissue injury and impaired cerebral perfusion.Mass Effect and Primary...
Hemorrhagic Stroke l: Introduction01:17

Hemorrhagic Stroke l: Introduction

A hemorrhagic stroke is an acute neurological event that occurs when a weakened cerebral blood vessel ruptures, allowing blood to accumulate within or around the brain. The sudden release of blood forms a focal hematoma that increases intracranial pressure, displaces neural tissue, and can obstruct cerebrospinal fluid pathways. These effects may be compounded by intraventricular extension of the hemorrhage, cerebral edema, or compression of adjacent structures, all of which contribute to...