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Updated: Jun 13, 2026
14:57
Yeast As a Chassis for Developing Functional Assays to Study Human P53
Published on: August 4, 2019
Posttranslational modification of p53: cooperative integrators of function
David W Meek1, Carl W Anderson
1Biomedical Research Institute, Ninewells Hospital and Medical School, University of Dundee, Dundee DD1 9SY, UK. d.w.meek@dundee.ac.uk
Cold Spring Harbor Perspectives in Biology
|May 12, 2010
Summary
The p53 protein undergoes numerous posttranslational modifications that work together. These cooperative events, rather than individual changes, collectively regulate p53 protein function.
Area of Science:
- Molecular Biology
- Cellular Stress Response
Background:
- The p53 protein is a critical tumor suppressor.
- p53 is regulated by extensive posttranslational modifications (PTMs).
- Over 50 distinct PTMs have been identified for p53.
Purpose of the Study:
- To explore the collective impact of p53 posttranslational modifications.
- To emphasize the interdependent nature of p53 PTMs.
- To present recent findings on cooperative modification events.
Main Methods:
- Review of recent scientific literature.
- Analysis of experimental data on p53 modification.
- Investigation of protein-protein interactions mediated by p53 PTMs.
Main Results:
- p53 PTMs exhibit significant interdependence, forming cooperative pathways.
- Individual p53 modifications often have subtle effects.
- Collective PTMs precisely regulate protein-protein interactions.
Conclusions:
- p53 function is regulated by integrated and collective modification events.
- The cooperative model explains the subtle phenotypes observed in singly or sparsely modified p53.
- Understanding these collective events is key to comprehending p53 regulation.
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