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Yeast As a Chassis for Developing Functional Assays to Study Human P53
14:57

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Published on: August 4, 2019

Posttranslational modification of p53: cooperative integrators of function

David W Meek1, Carl W Anderson

  • 1Biomedical Research Institute, Ninewells Hospital and Medical School, University of Dundee, Dundee DD1 9SY, UK. d.w.meek@dundee.ac.uk

Cold Spring Harbor Perspectives in Biology
|May 12, 2010
PubMed

Insights

The p53 protein undergoes numerous posttranslational modifications that work together. These cooperative events, rather than individual changes, collectively regulate p53 protein function.

Area of Science:

  • Molecular Biology
  • Cellular Stress Response

Background:

  • The p53 protein is a critical tumor suppressor.
  • p53 is regulated by extensive posttranslational modifications (PTMs).
  • Over 50 distinct PTMs have been identified for p53.

Purpose of the Study:

  • To explore the collective impact of p53 posttranslational modifications.
  • To emphasize the interdependent nature of p53 PTMs.
  • To present recent findings on cooperative modification events.

Main Methods:

  • Review of recent scientific literature.
  • Analysis of experimental data on p53 modification.
  • Investigation of protein-protein interactions mediated by p53 PTMs.

Main Results:

  • p53 PTMs exhibit significant interdependence, forming cooperative pathways.
  • Individual p53 modifications often have subtle effects.
  • Collective PTMs precisely regulate protein-protein interactions.

Conclusions:

  • p53 function is regulated by integrated and collective modification events.
  • The cooperative model explains the subtle phenotypes observed in singly or sparsely modified p53.
  • Understanding these collective events is key to comprehending p53 regulation.

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