Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Prochirality02:05

Prochirality

The concept of prochirality leads to the nomenclature of the individual faces of a molecule and plays a crucial role in the enantioselective reaction. It is a concept where two or more achiral molecules react to produce chiral products. A typical process is the reaction of an achiral ketone to generate a chiral alcohol. Here, the achiral reactant reacts with an achiral reducing agent, sodium borohydride, to generate an equimolar mixture of the chiral enantiomers of the product. For example, an...
Chirality02:25

Chirality

Chirality is a term that describes the lack of mirror symmetry in an object. In other words, chiral objects cannot be superposed on their mirror images. For example, our feet are chiral, as the mirror image of the left foot, the right foot, cannot be superposed on the left foot.
Chiral objects exhibit a sense of handedness when they interact with another chiral object. For example, our left foot can only fit in the left shoe and not in the right shoe. Achiral objects — objects that have...
Conformations of Cyclohexane02:11

Conformations of Cyclohexane

Cyclohexane does not exist in a planar form due to the high angle and torsional strain it would experience in the planar structure. Instead, it adopts non-planar chair and boat conformations.
The chair form is the most stable and derives its name from its resemblance to the “easy chair.” In the chair conformation, two carbon atoms are arranged out-of-plane — one above and one below, minimizing the torsional strain. In the chair form, the bond angle is very close to the ideal tetrahedral value,...
Fischer Projections02:18

Fischer Projections

Learning to draw Fischer projections of molecules and understanding their relevance plays a crucial role in the visual depiction of organic molecules. A Fischer projection is a two-dimensional projection on a planar surface to simplify the three-dimensional wedge–dash representation of molecules. This is especially helpful in the case of molecules with multiple chiral centers that can be difficult to draw. Here, all the bonds of interest are represented as horizontal or vertical lines. While...
Chirality at Nitrogen, Phosphorus, and Sulfur02:30

Chirality at Nitrogen, Phosphorus, and Sulfur

Chirality is most prevalent in carbon-based tetrahedral compounds, but this important facet of molecular symmetry extends to sp3-hybridized nitrogen, phosphorus and sulfur centers, including trivalent molecules with lone pairs. Here, the lone pair behaves as a functional group in addition to the other three substituents to form an analogous tetrahedral center that can be chiral.
A consequence of chirality is the need for enantiomeric resolution. While this is theoretically possible for all...
Molecules with Multiple Chiral Centers02:25

Molecules with Multiple Chiral Centers

Molecules that possess multiple chiral centers can afford a large number of stereoisomers. For instance, while some molecules like 2-butanol have one chiral center, defined as a tetrahedral carbon atom with four different substituents attached, several molecules like butane-2,3-diol have multiple chiral centers. A simple formula to predict the number of stereoisomers possible for a molecule with n chiral centers is 2n. However, there can be a lower number where some of the stereoisomers are...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

One-Pot, One-Step Mn-bis(imino)pyridine Complexes through Sonochemistry.

Inorganic chemistry·2026
Same author

Bioorthogonal Tuning of Hydrogel Stiffness Promotes Zonal Redifferentiation of Passaged Chondrocytes.

bioRxiv : the preprint server for biology·2026
Same author

The development of bioinspired copper complexes for CO<sub>2</sub> activation and hydration.

Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry·2026
Same author

Structures of nickel-, copper-, and zinc-salophen derivatives.

Acta crystallographica. Section C, Structural chemistry·2026
Same author

<i>Legionella pneumophila</i> Encodes a Peptidoglycan Recycling Machinery Critical for Survival within Macrophages.

ACS infectious diseases·2026
Same author

Hydrodefluorination of a Fluorobenzene Equivalent by Harnessing a P(III)/Pd(II)-P(V)/Pd(0) Redox Couple Using a P-CF<b><sub>3</sub></b>-Functionalized Benzazaphosphole.

Inorganic chemistry·2026

Related Experiment Video

Updated: Jun 13, 2026

Interactive Molecular Model Assembly with 3D Printing
06:15

Interactive Molecular Model Assembly with 3D Printing

Published on: August 13, 2020

The chiral crown conformation in paddlewheel complexes.

Andrew DeAngelis1, David T Boruta, Jean-Bernard Lubin

  • 1Brown Laboratory, Department of Chemistry and Biochemistry, Newark, DE 19803, USA.

Chemical Communications (Cambridge, England)
|May 12, 2010
PubMed
Summary

Chiral crown configurations are adopted by bimetallic paddlewheel complexes. This study examines the generality of this conformation by altering metals and chiral ligands, proposing a model for its formation.

More Related Videos

Construction and Systematical Symmetric Studies of a Series of Supramolecular Clusters with Binary or Ternary Ammonium Triphenylacetates
06:35

Construction and Systematical Symmetric Studies of a Series of Supramolecular Clusters with Binary or Ternary Ammonium Triphenylacetates

Published on: February 15, 2016

A Micropatterning Assay for Measuring Cell Chirality
08:07

A Micropatterning Assay for Measuring Cell Chirality

Published on: March 11, 2022

Related Experiment Videos

Last Updated: Jun 13, 2026

Interactive Molecular Model Assembly with 3D Printing
06:15

Interactive Molecular Model Assembly with 3D Printing

Published on: August 13, 2020

Construction and Systematical Symmetric Studies of a Series of Supramolecular Clusters with Binary or Ternary Ammonium Triphenylacetates
06:35

Construction and Systematical Symmetric Studies of a Series of Supramolecular Clusters with Binary or Ternary Ammonium Triphenylacetates

Published on: February 15, 2016

A Micropatterning Assay for Measuring Cell Chirality
08:07

A Micropatterning Assay for Measuring Cell Chirality

Published on: March 11, 2022

Area of Science:

  • Coordination Chemistry
  • Supramolecular Chemistry
  • Chiral Materials

Background:

  • Bimetallic paddlewheel complexes are versatile coordination compounds.
  • Imides of (S)-tert-leucine can form complexes with unique structural features.
  • The 'chiral crown' conformation describes a specific chiral arrangement of ligands.

Purpose of the Study:

  • To investigate the generality of the chiral crown conformation in bimetallic paddlewheel complexes.
  • To explore how variations in metal centers and chiral ligands influence this conformation.
  • To develop a model explaining the factors driving the chiral crown configuration.

Main Methods:

  • Crystallographic studies were employed to analyze the structures of the complexes.
  • Systematic variation of metal ions within the paddlewheel core.
  • Modification of the chiral imide ligands derived from (S)-tert-leucine.

Main Results:

  • The chiral crown conformation was observed to be a general feature across various metal substitutions.
  • The arrangement of imide and tert-butyl groups in the chiral crown was confirmed crystallographically.
  • The study identified key factors influencing the preference for the chiral crown configuration.

Conclusions:

  • The chiral crown conformation is a robust structural motif in these bimetallic complexes.
  • The findings provide insights into the stereochemical control in coordination chemistry.
  • A predictive model for the chiral crown configuration can be derived from these observations.