Catheter-directed thrombolysis of lower limb thrombosis

Area of Science:

• Vascular Surgery
• Interventional Radiology
• Thrombosis Management

Background:

• Late complications of suprapopliteal deep-vein thrombosis (DVT) are frequent and often overlooked.
• These complications include recurrent DVT and post-thrombotic syndrome, significantly impacting patient quality of life.

Purpose of the Study:

• To review the methods, safety, and efficacy of acute interventional treatment for suprapopliteal DVT.
• To highlight the benefits of pharmacomechanical thrombus clearance in early DVT management.

Main Methods:

• Review of recent interventional radiology techniques for thrombolysis.
• Focus on pharmacomechanical-assisted clearance of suprapopliteal DVT.

Main Results:

• Pharmacomechanical clearance offers the best opportunity for complete recovery.
• Preserves normal venous valve function and prevents recurrent DVT and post-thrombotic syndrome.
• Effective even in patients previously considered ineligible for thrombolysis.

Conclusions:

• Acute interventional treatment, particularly pharmacomechanical clearance, is crucial for managing suprapopliteal DVT.
• Early intervention improves outcomes and reduces long-term sequelae.
• Interventional radiology provides advanced, safe, and effective treatment options.