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Updated: Jun 13, 2026

Invasive Hemodynamic Assessment for the Right Ventricular System and Hypoxia-Induced Pulmonary Arterial Hypertension in Mice
Published on: October 24, 2019
Relations between respiratory changes in R-wave amplitude and arterial pulse pressure in mechanically ventilated
Maxime Cannesson1, Geoffray Keller, Olivier Desebbe
1Department of Anesthesiology & Perioperative Care, University of California, Irvine, Orange, 92868-3301, USA. maxime_cannesson@hotmail.com
Introduction:
R-wave obtained from the electrocardiogram depends on ventricular stroke volume. We assessed the relationship between respiratory variations in R-wave (DeltaRDII) and in pulse pressure (DeltaPP) during general anesthesia.
Method:
R-wave amplitude was measured from standard lead II (RDII). Maximal RDII (RDIImax) and minimal RDII (RDIImin) were determined over one respiratory cycle. DeltaRDII was calculated as 100 x [RDIImax-RDIImin]/([RDIImax + RDIImin]/2. DeltaRDII and DeltaPP were simultaneously recorded.
Results:
There was a significant relationship (r = 0.79; P < 0.001) between DeltaRDII and DeltaPP. A DeltaRDII > 13% detected patients with a DeltaPP > 13% with an 89% sensitivity, and an 88% specificity.
Conclusion:
DeltaRDII and DeltaPP are related in this setting.
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