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Updated: Jun 13, 2026

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Methods for the Discovery of Novel Compounds Modulating a Gamma-Aminobutyric Acid Receptor Type A Neurotransmission
Published on: August 16, 2018
[Modulators of the regulatory protein activity acting at microdoses]
Tsitologiia I Genetika
|May 13, 2010
Summary
New bioregulators from eye tissue are active at ultra-low doses. Their nanosize correlates with high potency, suggesting novel therapeutic potential for these regulatory peptides.
Area of Science:
- Ophthalmology
- Biochemistry
- Molecular Biology
Context:
- Vitreoretinal tissue contains novel bioactive molecules.
- Understanding ocular tissue composition is crucial for eye health research.
Purpose:
- To isolate and characterize previously unstudied bioregulators from eye tissue.
- To establish the relationship between bioregulator characteristics and their activity at ultra-low doses.
Summary:
- New bioregulators active at 10(-8) - 10(-17) mg/ml were isolated from eye vitreoretinal tissue.
- These bioregulators are regulatory peptides (proteins, 15-70 KDa), including bovine serum albumin.
- A correlation between the nanosize of these bioregulators and their ultra-low dose activity was established.
Impact:
- Discovery of novel, highly potent bioregulators from ocular tissue.
- Potential for developing new therapeutic agents targeting eye conditions.
- Highlights the significance of nanosize in biological activity at extremely low concentrations.
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