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Related Concept Videos

Electrospray Ionization (ESI) Mass Spectrometry01:12

Electrospray Ionization (ESI) Mass Spectrometry

Higher molecular weight biomolecules are nonvolatile compounds that may decompose before ionizing or vaporizing during mass analysis with conventional electron impact ionization methods. Accordingly, electrospray ionization (ESI) is the favored method for vaporizing and ionizing biomolecules as it circumvents rapid fragmentation and enables the recording of mass signals for the entire biomolecule.
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Tandem Mass Spectrometry01:21

Tandem Mass Spectrometry

Tandem mass spectrometry is a technique that uses multiple mass analyzers in series to obtain a higher selectivity and reduce chemical noise during analyte detection. Instruments with multiple analyzers separated by an interaction cell enable secondary fragmentation and selected study of the fragment ions.Secondary fragmentations occur in the interaction cell and can be induced by various factors. Fragmentation induced by collision with inert gases, such as N2, Ar, He, etc., is called...
Capillary Electrophoresis: Applications01:30

Capillary Electrophoresis: Applications

Capillary electrophoretic separations offer various modes, each with unique applications. These modes include capillary zone electrophoresis, capillary gel electrophoresis, capillary array electrophoresis, capillary isoelectric focusing, capillary isotachophoresis, micellar electrokinetic chromatography, and capillary electrochromatography.
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High-Performance Liquid Chromatography: Elution Process

In High-Performance Liquid Chromatography (HPLC), the elution process is critical to the separation of analytes and the quality of chromatographic results. Elution describes how compounds move through the column and separate based on their interactions with the mobile and stationary phases. This process determines the resolution, peak shape, and retention times in the chromatogram, which are essential for identifying and quantifying components in complex mixtures. Understanding the elution...
Mass Spectrometry: Complex Analysis01:21

Mass Spectrometry: Complex Analysis

Mass spectrometry is an important technique for the identification of pure compounds. However, it has some limitations for the analysis of complex mixtures, often due to excessive fragmentation making the spectrum too complicated to decipher. Mass spectrometry can be combined with suitable separation methods in sequence, forming hyphenated methods, which are useful in the analysis of complex mixtures.
GC–MS is a powerful hyphenated method commonly used in forensics and environmental...
Gas Chromatography: Sample Injection Systems01:08

Gas Chromatography: Sample Injection Systems

In gas chromatography, the sample is introduced as a vapor plug into the carrier gas stream for high efficiency and resolution. A microsyringe injects the sample solution into a heated sample port, vaporizing it and mixing it with the carrier gas. This process is important to ensure the sample is properly prepared for analysis. Thermally sensitive samples can be injected directly into the column and volatilized by slowly increasing the column temperature.
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High Throughput Single-cell and Multiple-cell Micro-encapsulation
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Multishell encapsulation using a triple coaxial electrospray system.

Woojin Kim1, Sang Soo Kim

  • 1Aerosol and Particle Technology Laboratory, School of Mechanical, Aerospace & Systems Engineering, Korea Advanced Institute of Science and Technology, Guseong-dong, Yuseong-gu, Daejeon 305-701, Republic of Korea.

Analytical Chemistry
|May 13, 2010
PubMed
Summary
This summary is machine-generated.

Researchers developed a novel electrospray method using a triple coaxial nozzle to create multishell capsules for drug delivery. This technique offers enhanced control over capsule size and shell thickness, improving potential applications.

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Fabrication of Spherical and Worm-shaped Micellar Nanocrystals by Combining Electrospray, Self-assembly, and Solvent-based Structure Control
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Area of Science:

  • Materials Science
  • Chemical Engineering
  • Drug Delivery Systems

Background:

  • Conventional encapsulation methods have limitations for drug delivery.
  • Electrospray technology offers potential for advanced encapsulation but requires refinement.

Purpose of the Study:

  • To develop an electrospray system for generating multishell capsules.
  • To enhance control over capsule size and shell thickness for drug delivery applications.

Main Methods:

  • Utilized a triple coaxial nozzle electrospray system.
  • Employed ethylene glycol, 4-hydroxybutyl acrylate (conducting fluids), and olive oil (nonconducting fluid).
  • Solidified capsules via photopolymerization and analyzed using dispersive Raman spectroscopy.

Main Results:

  • Successfully generated multishell capsules in an overlapped cone-jet mode.
  • Demonstrated control over capsule size and shell thickness by adjusting flow rates and applied voltages.
  • Verified chemical composition of the capsules using Raman spectroscopy.

Conclusions:

  • The triple coaxial nozzle electrospray system is effective for producing multishell capsules.
  • This method provides tunable control over capsule characteristics for potential drug delivery applications.
  • Offers an advancement over conventional encapsulation techniques.