Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Simulation of the effect of hemolysis on thrombosis in blood-contacting medical devices.

Medical engineering & physics·2024

Same author

Xanthomonas albilineans Haplotype B Responsible for a Recent Sugarcane Leaf Scald Disease Outbreak in Cuba.

Plant disease·2019

Same author

Beneficial Effects of High-Density Lipoproteins on Acquired von Willebrand Syndrome in Aortic Valve Stenosis.

Thrombosis and haemostasis·2018

Same author

The influence of composition and location on the toughness of human atherosclerotic femoral plaque tissue.

Acta biomaterialia·2015

Same author

Validation of fatty acid intakes estimated by a food frequency questionnaire using erythrocyte fatty acid profiling in the Montreal Heart Institute Biobank.

Journal of human nutrition and dietetics : the official journal of the British Dietetic Association·2014

Same author

A three-layer model for buckling of a human aortic segment under specific flow-pressure conditions.

International journal for numerical methods in biomedical engineering·2014

Search research articles

Related Experiment Video

Updated: Jun 13, 2026

Optical Coherence Tomography Based Biomechanical Fluid-Structure Interaction Analysis of Coronary Atherosclerosis Progression

Optical Coherence Tomography Based Biomechanical Fluid-Structure Interaction Analysis of Coronary Atherosclerosis Progression

Published on: January 15, 2022

Deformable mock stenotic artery with a lipid pool.

V Pazos¹, R Mongrain, J C Tardif

¹Department of Mechanical Engineering, McGill University, MacDonald Building, 817 Sherbrooke Street West, Montreal, QC, H3A 2K6, Canada.

Journal of Biomechanical Engineering

|May 13, 2010

Summary

Researchers developed a realistic, deformable mock coronary artery using polyvinyl alcohol cryogel. This test phantom mimics atherosclerosis, aiding in the evaluation of new intravascular imaging techniques and algorithms.

More Related Videos

Experimental Investigation of Secondary Flow Structures Downstream of a Model Type IV Stent Failure in a 180° Curved Artery Test Section

Experimental Investigation of Secondary Flow Structures Downstream of a Model Type IV Stent Failure in a 180° Curved Artery Test Section

Published on: July 19, 2016

A Magnetic Resonance Imaging-based Computational Protocol for Analysis of Plaque Morphology and Hemodynamics in Patients with Carotid Artery Stenosis

A Magnetic Resonance Imaging-based Computational Protocol for Analysis of Plaque Morphology and Hemodynamics in Patients with Carotid Artery Stenosis

Published on: August 12, 2025

Related Experiment Videos

Last Updated: Jun 13, 2026

Optical Coherence Tomography Based Biomechanical Fluid-Structure Interaction Analysis of Coronary Atherosclerosis Progression

Optical Coherence Tomography Based Biomechanical Fluid-Structure Interaction Analysis of Coronary Atherosclerosis Progression

Published on: January 15, 2022

Experimental Investigation of Secondary Flow Structures Downstream of a Model Type IV Stent Failure in a 180° Curved Artery Test Section

Experimental Investigation of Secondary Flow Structures Downstream of a Model Type IV Stent Failure in a 180° Curved Artery Test Section

Published on: July 19, 2016

A Magnetic Resonance Imaging-based Computational Protocol for Analysis of Plaque Morphology and Hemodynamics in Patients with Carotid Artery Stenosis

A Magnetic Resonance Imaging-based Computational Protocol for Analysis of Plaque Morphology and Hemodynamics in Patients with Carotid Artery Stenosis

Published on: August 12, 2025

Area of Science:

Biomedical Engineering
Medical Imaging
Materials Science

Background:

Realistic deformable test phantoms are crucial for evaluating new medical techniques.
Existing phantoms may not accurately replicate complex arterial structures like atherosclerotic coronary arteries.

Purpose of the Study:

To present a novel, multilayer deformable test specimen that mimics an atherosclerotic human coronary artery.
To create a phantom suitable for mechanical testing and intravascular imaging modalities.

Main Methods:

Constructed a three-layer mock artery using polyvinyl alcohol (PVA) cryogel with a lipid pool.
Employed molds for precise layer formation, mimicking intima-media and adventitia.
Acquired intravascular ultrasound (IVUS) images during mechanical deformation (stretching and inflation).

Main Results:

The mock artery exhibits a 25% lumen narrowing and includes a lipid pool, simulating atherosclerotic conditions.
Layer thicknesses (0.4 mm inner, 0.6 mm outer) approximate human coronary artery dimensions.
IVUS imaging successfully visualized and differentiated the mock artery's components.

Conclusions:

The developed double-layer stenotic mock artery is a size-appropriate, customizable tool for testing.
It is suitable for intravascular ultrasound imaging and mechanical evaluation of atherosclerotic models.
This phantom facilitates the optimization of new algorithms and techniques for diagnosing and treating coronary artery disease.