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Biological Compatibility Profile on Biomaterials for Bone Regeneration
Published on: November 16, 2018
Incorporation of tocopherol acetate-containing particles in acrylic bone cement
A Bettencourt1, H F Florindo, I F S Ferreira
1Research Institute for Medicines and Pharmaceutical Sciences (iMed.UL), Faculty of Pharmacy, University of Lisbon, Av. Prof. Gama Pinto, 1649-003 Lisbon, Portugal. asimao@ff.ul.pt
Journal of Microencapsulation
|May 13, 2010
Summary
Tocopherol acetate (ATA)-loaded polymethylmethacrylate (PMMA) particles offer a novel method for incorporating antioxidants into acrylic bone cement (BC). This approach preserves the mechanical properties of bone cement, crucial for successful orthopedic implant anchoring.
Area of Science:
- Biomaterials Science
- Orthopedic Surgery
- Drug Delivery Systems
Background:
- Acrylic bone cement (BC) is vital for anchoring orthopedic prostheses.
- Reactive species contribute to implant failure, necessitating antioxidant strategies.
- Directly incorporating antioxidants into BC can compromise mechanical integrity.
Purpose of the Study:
- To develop and evaluate tocopherol acetate (ATA)-loaded polymethylmethacrylate (PMMA) particles as carriers for BC.
- To investigate the drug release kinetics and mechanisms of ATA from PMMA particles and within BC.
- To assess the impact of ATA(PMMA) particles on the mechanical properties of BC.
Main Methods:
- ATA-loaded PMMA particles synthesized using single emulsion solvent evaporation.
- Encapsulation efficiency determined.
- In vitro drug release studies conducted and analyzed using kinetic models (first-order, Higuchi, Korsmeyer-Peppas).
- Mechanical properties of BC with and without ATA(PMMA) particles tested.
Main Results:
- High encapsulation efficiency of 84% achieved for ATA in PMMA particles.
- Distinct ATA release profiles observed: Fickian diffusion from particles, non-Fickian transport upon BC incorporation.
- No adverse effects on the mechanical properties of BC when incorporating ATA(PMMA) particles.
Conclusions:
- ATA(PMMA) particles effectively encapsulate tocopherol acetate.
- These particles serve as promising carriers for antioxidants in bone cement.
- This method avoids the mechanical degradation associated with direct antioxidant incorporation into BC.
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