Related Experiment Video

Updated: Jun 13, 2026

Extracellular Protein Microarray Technology for High Throughput Detection of Low Affinity Receptor-Ligand Interactions
06:01

Extracellular Protein Microarray Technology for High Throughput Detection of Low Affinity Receptor-Ligand Interactions

Published on: January 7, 2019

RAGE: a multi-ligand receptor unveiling novel insights in health and disease

P Alexiou1, M Chatzopoulou, K Pegklidou

  • 1Department of Pharmaceutical Chemistry, School of Pharmacy, Aristotle University of Thessaloniki, 54124 Greece. ksenia@pharm.auth.gr

Current Medicinal Chemistry
|May 13, 2010
PubMed

Insights

The Receptor for Advanced Glycation End products (RAGE) pathway is complex and linked to various diseases. Blockading RAGE shows promise as a therapeutic strategy for chronic conditions.

Area of Science:

  • Molecular biology
  • Immunology
  • Pharmacology

Background:

  • Receptor for Advanced Glycation End products (RAGE) is a cell surface molecule involved in various cellular processes.
  • RAGE interacts with diverse ligands, including advanced glycation end products (AGEs), amyloid fibrils, and S100/calgranulins.
  • RAGE is implicated in numerous pathological conditions, such as diabetes, Alzheimer's disease, cancer, and inflammation.

Purpose of the Study:

  • To review the fundamental biology of RAGE and its associated signaling pathways in health and disease.
  • To explore the therapeutic potential of targeting the RAGE pathway for chronic disease management.
  • To present an overview of pharmacotherapeutic agents developed for RAGE blockade.

Main Methods:

  • Literature review of RAGE biology, signaling, and therapeutic targets.
  • Analysis of RAGE's role in various disease pathologies.
  • Compilation of existing and emerging RAGE-blocking agents.

Main Results:

  • RAGE's multi-ligand binding and signaling cascades contribute to a wide range of diseases.
  • Genetic variations in RAGE can influence its functional activity.
  • Several pharmacotherapeutic agents targeting RAGE have been developed, indicating its potential as a drug target.

Conclusions:

  • The RAGE pathway is a significant factor in numerous chronic diseases.
  • Targeting RAGE presents a promising therapeutic avenue for conditions like diabetes, Alzheimer's, cancer, and inflammation.
  • Further research into RAGE blockade strategies is warranted to assess safety and efficacy for disease prevention and treatment.

More Related Videos

Parallel Interrogation of β-Arrestin2 Recruitment for Ligand Screening on a GPCR-Wide Scale using PRESTO-Tango Assay09:03

Parallel Interrogation of β-Arrestin2 Recruitment for Ligand Screening on a GPCR-Wide Scale using PRESTO-Tango Assay

Published on: March 10, 2020

A Flow Cytometry-based Assay to Identify Compounds That Disrupt Binding of Fluorescently-labeled CXC Chemokine Ligand 12 to CXC Chemokine Receptor 406:56

A Flow Cytometry-based Assay to Identify Compounds That Disrupt Binding of Fluorescently-labeled CXC Chemokine Ligand 12 to CXC Chemokine Receptor 4

Published on: March 10, 2018

Related Concept Videos

G Protein-coupled Receptors01:15

G Protein-coupled Receptors

G Protein-Coupled Receptors or GPCRs are membrane-bound receptors that transiently associate with heterotrimeric G proteins and induce an appropriate response to sensory stimuli such as light, odors, hormones, cytokines, or neurotransmitters.
GPCRs are also called heptahelical, 7TM, or serpentine receptors, and consist of seven (H1-H7) transmembrane alpha-helices that span the bilayer to form a cylindrical core. The transmembrane helices are connected by three extracellular loops and three...
G Protein-coupled Receptors01:15

G Protein-coupled Receptors

G Protein-Coupled Receptors or GPCRs are membrane-bound receptors that transiently associate with heterotrimeric G proteins and induce an appropriate response to sensory stimuli such as light, odors, hormones, cytokines, or neurotransmitters.
GPCRs are also called heptahelical, 7TM, or serpentine receptors, and consist of seven (H1-H7) transmembrane alpha-helices that span the bilayer to form a cylindrical core. The transmembrane helices are connected by three extracellular loops and three...
Ligand Binding Sites02:40

Ligand Binding Sites

Proteins are dynamic macromolecules that carry out a wide variety of essential processes; however, the activities of most proteins depend on their interactions with other molecules or ions, known as ligands.
Protein-ligand interactions are quite specific; even though numerous potential ligands surround a cellular protein at any given time, only a particular ligand can bind to that protein. Moreover, a ligand binds only to a dedicated area on the surface of the protein, known as the...
Ligand Binding Sites02:40

Ligand Binding Sites

Proteins are dynamic macromolecules that carry out a wide variety of essential processes; however, the activities of most proteins depend on their interactions with other molecules or ions, known as ligands.
Protein-ligand interactions are quite specific; even though numerous potential ligands surround a cellular protein at any given time, only a particular ligand can bind to that protein. Moreover, a ligand binds only to a dedicated area on the surface of the protein, known as the...
Ligand Binding and Linkage00:49

Ligand Binding and Linkage

Allosteric proteins have more than one ligand binding site; the binding of a ligand to any of these sites influences the binding of ligands to the other sites. When a protein is allosteric, its binding sites are called coupled or linked.  In the case of enzymes, the site that binds to the substrate is known as the active site and the other site is known as the regulatory site. When a ligand binds to the regulatory site, this leads to conformational changes in the protein that can influence the...
Ligand Binding and Linkage00:49

Ligand Binding and Linkage

Allosteric proteins have more than one ligand binding site; the binding of a ligand to any of these sites influences the binding of ligands to the other sites. When a protein is allosteric, its binding sites are called coupled or linked.  In the case of enzymes, the site that binds to the substrate is known as the active site and the other site is known as the regulatory site. When a ligand binds to the regulatory site, this leads to conformational changes in the protein that can influence the...