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Canine synovial myxoma: 39 cases.
L E Craig1, P M Krimer, A J Cooley
1Department of Pathobiology, University of Tennessee, College of Veterinary Medicine, 2407 River Drive, Knoxville, TN 37996-4542, USA. linden@utk.edu
Veterinary Pathology
|May 13, 2010
Summary
Canine synovial myxoma, a tumor affecting large dogs, presents as gelatinous nodules. These tumors have a good prognosis, with affected dogs experiencing long survival times even after incomplete surgical removal.
Area of Science:
- Veterinary Pathology
- Canine Oncology
- Soft Tissue Tumors
Background:
- Canine synovial myxoma is a rare tumor.
- Understanding its characteristics is crucial for diagnosis and treatment.
Purpose of the Study:
- To describe the signalment, clinical, histological, and immunohistochemical features of canine synovial myxoma.
- To evaluate the behavior and prognosis of this tumor in dogs.
Main Methods:
- Retrospective review of 39 canine synovial myxoma cases.
- Analysis of clinical, radiographic, gross, histological, and immunohistochemical data.
- Evaluation of tumor behavior, including recurrence, metastasis, and survival.
Main Results:
- Most affected dogs were large-breed, middle-aged canines, particularly Doberman Pinschers and Labrador Retrievers.
- The stifle and digit were the most common tumor locations. Tumors were gelatinous nodules with potential for bony lysis or invasive growth.
- Histologically, tumors showed sparse cellularity within a myxomatous matrix. Immunohistochemistry revealed specific cell markers (vimentin, HSP25, cadherin 11) and variable CD18 expression.
Conclusions:
- Canine synovial myxoma is a histologically distinct tumor with a favorable prognosis.
- Affected dogs demonstrate long survival times, with low rates of recurrence and no metastasis.
- Complete surgical excision may not be necessary for a good outcome.
