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Updated: Jun 13, 2026

Mass Cytometry Analysis of Systemic and Local Immune Responses in Hepatocellular Carcinoma
Published on: April 25, 2025
Immune responses in hepatocellular carcinoma
Firouzeh Korangy1, Bastian Höchst, Michael P Manns
1Department of Gastroenterology, Hepatology and Endocrinology, Hannover Medical School, Hannover, Germany.
Hepatocellular carcinoma (HCC) is a leading cause of cancer death. Targeting immune suppressor cells, alone or with immunotherapy, may improve treatment for HCC patients by overcoming tumor immune evasion.
Area of Science:
- Oncology
- Immunology
- Cancer Research
Background:
- Hepatocellular carcinoma (HCC) is a significant global cause of cancer mortality.
- Immunotherapy is a promising treatment for HCC, but tumors develop immune escape mechanisms.
- Immune suppressor cells, like regulatory T cells and myeloid-derived suppressor cells, hinder anti-tumor immune responses in HCC.
Purpose of the Study:
- To explore the potential of targeting immune suppressor cells in Hepatocellular Carcinoma (HCC) treatment.
- To evaluate strategies for overcoming tumor-induced immune suppression in HCC patients.
Main Methods:
- Review of pathogenesis and correlative studies related to HCC and immunotherapy.
- Analysis of immune escape mechanisms employed by HCC tumors.
- Identification of suppressor cell populations masking anti-tumor immunity.
Main Results:
- Tumors generate immune suppressor cells that mask anti-tumor immune responses in HCC.
- Regulatory T cells and myeloid-derived suppressor cells are key components of this immune suppression.
Conclusions:
- Targeting immune suppressor cells presents a potential therapeutic strategy for HCC.
- Combination therapy, involving suppressor cell targeting and conventional immunotherapy, warrants further investigation in HCC patients.
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