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Published on: September 13, 2018
Peripheral nerve dysfunction in patients with cystic fibrosis
Khalid El-Salem1, Samah Aburahma, Mohammad Rawashdeh
1Department of Neurosciences, Faculty of Medicine, Jordan University of Science and Technology, Irbid, Jordan. khalidelsalem@hotmail.com
Summary
Cystic fibrosis (CF) is linked to peripheral nerve dysfunction, primarily affecting sensory nerves. This study highlights the need for awareness of these neurological issues in CF patients.
Area of Science:
- Neurology
- Pediatrics
- Genetics
Background:
- Cystic Fibrosis (CF) affects multiple organ systems.
- Peripheral nerve dysfunction is a potential complication.
- Understanding its prevalence and characteristics is crucial.
Purpose of the Study:
- To determine the frequency, magnitude, and nature of peripheral nerve dysfunction in pediatric CF patients.
- To identify specific nerve involvement and electrodiagnostic patterns.
- To assess the relationship between neuropathy and clinical factors.
Main Methods:
- Nerve conduction studies were performed on motor and sensory nerves in pediatric CF patients.
- Electrodiagnostic criteria for distal polyneuropathy were applied.
- Data were analyzed for correlations with patient demographics and CF characteristics.
Main Results:
- 56% of CF patients exhibited abnormal nerve conduction studies, exclusively in sensory nerves.
- Ulnar (48%), sural (44%), and median (28%) sensory nerves were most frequently affected.
- 40% met criteria for distal polyneuropathy; neuropathy was unrelated to sex, age, or disease severity.
Conclusions:
- Cystic Fibrosis is associated with sensory-predominant peripheral nerve dysfunction with an axonal pattern.
- Healthcare providers should monitor for neurological complications in CF patients.
- Improved survival in CF necessitates attention to associated peripheral neuropathies.
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