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Lutein absorption in premature infants
C Romagnoli1, C Tirone, S Persichilli
1Division of Neonatology, Department of Paediatrics, Catholic University of the Sacred Heart, Rome, Italy. cromagnoli@rm.unicatt.it
European Journal of Clinical Nutrition
|May 13, 2010
Summary
Oral lutein supplementation is well-absorbed in preterm infants, leading to increased plasma lutein concentrations. Further research is needed to determine the clinical impact on infant macular development and visual function.
Area of Science:
- Neonatal Nutrition
- Ophthalmology
- Pharmacokinetics
Background:
- Preterm infants have unique nutritional needs.
- Lutein and zeaxanthin are crucial carotenoids for visual development.
- Limited data exists on lutein absorption in preterm neonates.
Purpose of the Study:
- To measure plasma lutein and zeaxanthin levels in preterm infants following oral lutein administration.
- To assess the absorption and pharmacokinetic profile of lutein in this population.
Main Methods:
- A single oral dose of 0.5 mg/kg lutein was administered to 10 preterm infants.
- Plasma lutein and zeaxanthin were quantified at baseline and at 6, 24, 48, and 120 hours post-administration.
- Pre-treatment plasma levels of both carotenoids were already detectable.
Main Results:
- Plasma lutein concentrations increased by 13.5% at 6 hours and 16.7% at 24 hours post-dose.
- Lutein levels returned to baseline by 120 hours.
- Plasma zeaxanthin levels remained unchanged throughout the study period.
Conclusions:
- Oral administration of lutein is well-absorbed in preterm infants.
- The study demonstrates the feasibility of lutein supplementation in neonates.
- Further investigation is warranted to explore the clinical significance of elevated lutein for macular and visual development.
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