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Related Experiment Video

Updated: Jun 13, 2026

High-definition Transcranial Direct Current Stimulation over Right Dorsolateral Prefrontal Cortex to Enhance Metacognitive Sensitivity
06:11

High-definition Transcranial Direct Current Stimulation over Right Dorsolateral Prefrontal Cortex to Enhance Metacognitive Sensitivity

Published on: September 26, 2025

Improving prefrontal cortex function in schizophrenia through focused training of cognitive control.

Bethany G Edwards1, Deanna M Barch, Todd S Braver

  • 1Departments of Psychology, Washington University St. Louis, MO, USA.

Frontiers in Human Neuroscience
|May 13, 2010
PubMed
Summary

Strategy training improved cognitive control in schizophrenia patients by normalizing brain activity in the lateral prefrontal cortex (PFC). This enhancement correlated with symptom reduction and better task performance.

Keywords:
cognitive controlcognitive trainingfunctional imagingprefrontal cortexremediationschizophrenia

Related Experiment Videos

Last Updated: Jun 13, 2026

High-definition Transcranial Direct Current Stimulation over Right Dorsolateral Prefrontal Cortex to Enhance Metacognitive Sensitivity
06:11

High-definition Transcranial Direct Current Stimulation over Right Dorsolateral Prefrontal Cortex to Enhance Metacognitive Sensitivity

Published on: September 26, 2025

Area of Science:

  • Neuroscience
  • Cognitive Psychology
  • Psychiatry

Background:

  • Individuals with schizophrenia exhibit cognitive control deficits linked to lateral prefrontal cortex (PFC) dysfunction.
  • Impaired utilization of contextual cues and altered brain activity dynamics are observed in schizophrenia patients during cognitive tasks.

Purpose of the Study:

  • To investigate the impact of instructed strategy training on cognitive control functioning in schizophrenia.
  • To examine if strategy training alters brain activity dynamics within cognitive control networks, particularly the lateral PFC.

Main Methods:

  • Event-related functional magnetic resonance imaging (fMRI) was employed to assess brain activity changes.
  • Schizophrenia patients (N=22) underwent the AX-CPT task pre- and post-strategy training.
  • Healthy controls (N=14) were scanned pre-training for comparison.

Main Results:

  • Pre-training, schizophrenia patients showed impaired cue utilization and altered activation patterns in PFC-centered networks.
  • Post-training, patients exhibited normalized activation dynamics, shifting towards patterns seen in controls.
  • These neural changes correlated with improvements in behavioral performance and reductions in clinical symptoms.

Conclusions:

  • Focused strategy training can enhance cognitive task performance in schizophrenia.
  • Training-induced improvements are associated with modifications in brain activity dynamics within critical cognitive control regions.
  • This suggests a potential therapeutic avenue for cognitive deficits in schizophrenia.