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Multiplexed Fluorescent Immunohistochemical Staining, Imaging, and Analysis in Histological Samples of Lymphoma
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Published on: January 9, 2019

Cellular density evaluation for malignant lymphoma using equivalent cross-relaxation rate imaging - initial

Hideyuki Nishiofuku1, Shigeru Matsushima, Yoshitaka Inaba

  • 1Department of Radiology, Nara Medical University, Kashihara, Nara, Japan. nishiofukuhideyuki@yahoo.co.jp

Korean Journal of Radiology
|May 13, 2010
PubMed
Summary

Equivalent cross-relaxation rate (ECR) imaging shows promise for differentiating follicular lymphoma (FL) from diffuse large B-cell lymphoma (DLBCL). This MRI technique correlates strongly with cellular density, offering a potential tool for histologic classification of malignant lymphoma.

Keywords:
Cellular imagingEquivalent cross-relaxation rate imagingMalignant lymphomaMolecular imaging

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Area of Science:

  • Magnetic Resonance Imaging (MRI)
  • Biophysics
  • Oncology

Background:

  • Equivalent cross-relaxation rate (ECR) imaging quantifies protein-water interactions.
  • Histologic classification of malignant lymphoma (ML) is crucial for treatment.
  • Differentiating between follicular lymphoma (FL) and diffuse large B-cell lymphoma (DLBCL) is clinically significant.

Purpose of the Study:

  • To evaluate the utility of ECR imaging in the histologic classification of ML.
  • To assess if ECR imaging can differentiate between FL and DLBCL.
  • To investigate the correlation between ECR values and cellular density in ML.

Main Methods:

  • Retrospective study of 15 untreated ML patients (8 FL, 7 DLBCL).
  • All patients underwent ECR imaging with an offset frequency of 7 ppm.
  • ECR values and cellular density were measured and compared between FL and DLBCL groups.

Main Results:

  • Median ECR values were significantly higher in FL (71%) compared to DLBCL (54%) (p=0.001).
  • Median cellular density was also significantly higher in FL (1.5 x 10^6/mm^2) than DLBCL (1.0 x 10^6/mm^2) (p=0.001).
  • A strong positive correlation (r=0.88, p=0.001) was found between ECR values and cellular density in ML. ECR imaging achieved 100% sensitivity and specificity for differentiating FL and DLBCL using a 60% cutoff.

Conclusions:

  • ECR imaging demonstrates a strong correlation with cellular density in malignant lymphoma.
  • ECR imaging is a potentially valuable non-invasive technique for differentiating between FL and DLBCL.
  • This MRI technique may aid in the histologic classification of lymphoma subtypes.