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Related Concept Videos

Drug Dosing: Geriatric Patients01:15

Drug Dosing: Geriatric Patients

206
Elderly individuals encompass a diverse population with varying degrees of age-related physiological changes. Defining the elderly presents challenges, as the geriatric population is often arbitrarily categorized as individuals older than 65. However, many individuals in this group lead active and healthy lives, with an increasing number surpassing 85 years and falling into the older elderly category. Physiological changes associated with aging impact performance capacity and homeostatic...
206
Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Absorption01:22

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Absorption

205
As individuals age, their body's physiology evolves, affecting drug pharmacokinetics. The most apparent changes occur in the gastrointestinal tract, where an increase in gastric pH, a delay in gastric emptying, and a reduction in gastrointestinal motility are observed. Remarkably, these changes do not substantially modify the absorption of orally administered drugs, particularly those absorbed via passive diffusion.Transdermal drug delivery emerges as a highly viable method for older adults due...
205
Pharmacodynamics in Geriatric Patients: Effects of Age01:27

Pharmacodynamics in Geriatric Patients: Effects of Age

174
Age-related pharmacokinetic changes are extensively documented, but understanding age-related pharmacodynamic alterations is relatively limited. This knowledge gap can be partly attributed to the complexity of developing appropriate measures of drug responses compared to bioanalytical methods for determining drug concentrations.Most information regarding age-related differences in human pharmacodynamics originates from cross-sectional studies. However, these studies assume that observed mean...
174

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Related Experiment Video

Updated: Jan 7, 2026

Human Neural Organoids for Studying Brain Cancer and Neurodegenerative Diseases
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Primary brain tumors in the elderly.

Lakshmi Nayak1, Fabio M Iwamoto

  • 1Department of Neurology, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, New York, NY 10065, USA. nayakl@mskcc.org

Current Neurology and Neuroscience Reports
|May 13, 2010
PubMed
Summary

Elderly patients with primary brain tumors can benefit from individualized treatment plans. Age should not prevent aggressive therapies like surgery, radiation, and chemotherapy for select patients.

Area of Science:

  • Neuro-oncology
  • Geriatric Medicine
  • Clinical Oncology

Background:

  • Primary brain tumors are most common in elderly patients, with advanced age often indicating a poor prognosis.
  • Large randomized studies in this demographic are limited, and older patients face unique challenges like comorbidities and treatment toxicities.
  • This review focuses on treatment strategies for glioblastoma, gliomas, primary central nervous system lymphomas (PCNSLs), and meningiomas in older adults.

Purpose of the Study:

  • To provide an overview of treatment options for primary brain tumors in elderly patients.
  • To discuss the specific challenges and considerations for treating brain tumors in older individuals.
  • To emphasize individualized treatment approaches based on patient performance status and tumor type.

Main Methods:

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  • Literature review of treatment options for primary brain tumors in elderly populations.
  • Analysis of challenges including comorbidities, polypharmacy, and treatment tolerance.
  • Evaluation of treatment strategies for glioblastoma, PCNSLs, and meningiomas in older adults.

Main Results:

  • Selected elderly glioblastoma patients with good performance status may tolerate aggressive multimodal therapy (surgery, radiotherapy, chemotherapy).
  • High-dose methotrexate-based chemotherapy is recommended for older patients with PCNSLs; whole-brain radiation therapy should be used cautiously due to neurotoxicity risks.
  • Meningiomas in elderly patients are often managed with observation due to slow growth and asymptomatic presentation.

Conclusions:

  • Treatment for elderly patients with primary brain tumors must be individualized.
  • Age alone should not be a barrier to aggressive treatment when appropriate.
  • Careful consideration of comorbidities and performance status is crucial for optimizing outcomes.