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Pharmacokinetics in Pediatric Patients: Drug Distribution

Pharmacokinetics in Pediatric Patients: Drug Distribution

Drug distribution in the pediatric population exhibits unique challenges and considerations due to the physiological differences between children, particularly neonates and infants, and adults. A crucial aspect of pediatric pharmacology is understanding how these differences impact the pharmacokinetics of various drugs, necessitating age-specific dosing strategies to ensure efficacy and safety.Neonates and infants have a higher total body water content, ~75%–90% of their body weight, compared...

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In pediatric medicine, understanding the renal function and drug elimination nuances is crucial for administering safe and effective treatments. Newborns, in particular, display markedly slower renal functions than adults, profoundly affecting how drugs are cleared from their bodies. This slower drug clearance requires clinicians to extend the dosing intervals for many medications to prevent drug accumulation and toxicity while ensuring therapeutic efficacy.One key area where these adjustments...

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Updated: Jun 13, 2026

Guidelines for Elective Pediatric Fiberoptic Intubation

Guidelines for Elective Pediatric Fiberoptic Intubation

Published on: January 17, 2011

Children's rights in pediatrics.

Jürg C Streuli¹, Margot Michel, Effy Vayena

¹Institute of Biomedical Ethics, University of Zurich, Pestalozzistr. 24, CH-8032, Zürich, Switzerland. streuli@ethik.uzh.ch

European Journal of Pediatrics

|May 13, 2010

Summary

This summary is machine-generated.

Pediatricians daily encounter children's rights, yet lack systematic training on the United Nations Convention of Children's Rights (UNCRC). This article provides a checklist to help clinicians uphold children's rights in practice.

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Last Updated: Jun 13, 2026

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Making MR Imaging Child's Play - Pediatric Neuroimaging Protocol, Guidelines and Procedure

Making MR Imaging Child's Play - Pediatric Neuroimaging Protocol, Guidelines and Procedure

Published on: July 30, 2009

Area of Science:

Pediatric healthcare
Human rights law
Child advocacy

Background:

The United Nations Convention of Children's Rights (UNCRC), established in 1989, significantly shifted global perspectives on child protection.
Pediatric healthcare professionals routinely engage with children, inherently involving children's rights in their daily practice.
Despite the relevance of at least 18 UNCRC articles to pediatrics, systematic training on supporting these rights in clinical settings is limited.

Purpose of the Study:

To discuss the core principles and objectives of the UNCRC.
To bridge the gap between UNCRC principles and pediatric clinical practice.
To equip pediatricians with practical tools for upholding children's rights.

Main Methods:

Review of the United Nations Convention of Children's Rights (UNCRC) principles.
Analysis of UNCRC articles pertinent to pediatric healthcare.
Development of a comprehensive checklist linking clinical issues to children's rights.

Main Results:

Identified at least 18 UNCRC articles directly applicable to pediatric practice.
Highlighted a deficit in systematic training for pediatricians regarding children's rights.
Proposed a practical checklist for integrating children's rights into clinical encounters.

Conclusions:

Pediatricians play a crucial role in advocating for children's rights within the healthcare system.
Enhanced training and practical tools, such as the proposed checklist, are essential for pediatricians to effectively support children's rights.
Implementing the UNCRC in clinical practice can lead to improved child well-being and healthcare outcomes.