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Updated: Jun 13, 2026
06:51
Studies of Chaperone-Cochaperone Interactions using Homogenous Bead-Based Assay
Published on: July 21, 2021
Study of cross-reactivity between proton pump inhibitors
M T Sobrevia Elfau1, M Garcés Sotillos, L Ferrer Clavería
1Hospital Clinico Universitario Lozano Blesa, Zaragoza, Spain. materesas@hotmail.com
Summary
This study confirms cross-reactivity between all proton pump inhibitors (PPIs) in patients with omeprazole allergy. Skin testing is crucial for diagnosing PPI allergy, though its accuracy decreases over time.
Area of Science:
- Allergy and Immunology
- Pharmacology
- Dermatology
Background:
- Proton pump inhibitors (PPIs) are widely used medications.
- Previous research suggests varying cross-reactivity patterns among different PPIs.
- Accurate diagnosis of PPI allergy is essential for patient safety.
Observation:
- The study involved 5 patients with a confirmed clinical allergy to omeprazole.
- Skin prick and intradermal tests were performed using all commercially available PPIs.
- All patients exhibited positive reactions to multiple PPIs during skin testing.
Findings:
- Confirmed immunoglobulin (Ig) E-mediated allergy to omeprazole in all 5 cases.
- Demonstrated significant cross-reactivity between all tested commercially available PPIs.
- Observed a decline in the probability of confirming IgE-mediated mechanisms with skin tests over time.
Implications:
- Establishes a procedure for cutaneous testing to verify PPI allergy.
- Highlights the high degree of cross-reactivity, suggesting caution when switching PPIs in allergic patients.
- Proposes a potential hypothesis to explain observed PPI cross-reactivity patterns, warranting further investigation.
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