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Is there evidence of separate inflammatory or metabolic forms of preeclampsia?
Sandra A Founds1, Janet M Catov, Marcia J Gallaher
1School of Nursing, University of Pittsburgh, Pittsburgh, PA, USA. foundss@pitt.edu
Objectives:
To examine whether high insulin resistance versus high inflammation identifies subtypes of preeclampsia.
Methods:
A cytokine panel, glucose and insulin were measured in 37 preeclampsia plasma samples. Wilcoxon rank sum assessed median concentration of HOMA(IR) by pro-inflammatory:anti-inflammatory ratio. Regression stratifying by BMI and preterm birth was conducted.
Results:
There was no difference in median HOMA(IR) by the pro-inflammatory:anti-inflammatory ratio (p = 0.16). No subsets scatterplot clusters emerged. A positive correlation between HOMAlog and the ratio was significant (p = 0.04).
Conclusions:
No dichotomous subsets of preeclampsia by inflammation versus insulin resistance were detected. Contrary to our hypothesis, insulin resistance was higher as inflammation increased in preeclampsia.
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