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Reactive nonsexually related acute genital ulcers: review of cases evaluated at Mayo Clinic
Julia S Lehman1, Alison J Bruce, David A Wetter
1Division of Clinical Dermatology, Mayo Clinic, Rochester, Minnesota 55905, USA.
Background:
Reactive nonsexually related acute genital ulcers (RNSRAGU) occur in pubertal girls after an acute systemic infection.
Objective:
We sought to characterize RNSRAGU by reviewing the medical records of patients with this disorder.
Methods:
We searched our medical index database from 1997 to 2007 for RNSRAGU cases. Questionnaires were mailed to identified patients.
Results:
The study included 10 patients; 5 responded to the questionnaire. The mean age at onset was 11.5 years. Vulvar ulcers were preceded by viral gastroenteritis (n = 3), viral upper respiratory tract infection (n = 3), streptococcal pharyngitis (n = 1), influenza (n = 1), and other nonspecific febrile illnesses (n = 2). Seven patients had oral involvement also; 6 had at least one recurrence; and 3 were hospitalized for pain control. Analgesics and topical corticosteroids were the most common treatments. Ulcerations resolved within several weeks in all patients.
Limitations:
Retrospective study design, small study size, and 50% questionnaire response rate are limitations.
Conclusions:
Although rare, RNSRAGU should be considered when genital ulceration follows an acute systemic illness.
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