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Related Experiment Video

Updated: Jun 13, 2026

A Magnetic Resonance Imaging Protocol for Stroke Onset Time Estimation in Permanent Cerebral Ischemia

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Published on: September 16, 2017

Diffusion-weighted MRI in acute stroke within the first 6 hours: 1.5 or 3.0 Tesla?

C Rosso¹, A Drier, D Lacroix

¹AP-HP, Urgences Cérébro-Vasculaires, Université Pierre et Marie Curie, Paris VI, Hôpital Pitié-Salpêtrière, Paris, France. charlotte.rosso@gmail.com

|May 14, 2010

Summary

1.5-T diffusion-weighted MRI (DWI) demonstrates superior accuracy and sensitivity for detecting hyperacute ischemic stroke lesions compared to 3.0-T DWI. This finding is crucial for timely diagnosis and treatment within the thrombolysis window.

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Area of Science:

Radiology
Neurology
Medical Imaging

Background:

Diffusion-weighted MRI (DWI) is essential for diagnosing acute ischemic stroke.
Magnetic field strength (1.5 T vs. 3.0 T) may influence DWI performance.
Optimizing imaging for hyperacute stroke detection is critical for therapeutic interventions.

Purpose of the Study:

To compare the diagnostic accuracy, sensitivity, and specificity of 1.5-T and 3.0-T DWI for detecting hyperacute ischemic stroke.
To evaluate the impact of magnetic field strength on DWI performance in the early hours of stroke onset.

Main Methods:

Retrospective analysis of DWI scans from 135 acute ischemic stroke patients and 34 controls.
Scans were performed at 1.5 T (n=108) or 3.0 T (n=61) within 6 hours of stroke onset.
Four blinded readers assessed lesion detection; quantitative metrics like SNR and CNR were calculated.

Main Results:

1.5-T DWI showed higher diagnostic accuracy (98.8%) than 3.0-T DWI (90.9%, p=0.03).
Sensitivity was higher for 1.5-T (99.1%) vs. 3.0-T (92.5%), and specificity was significantly higher for 1.5-T (97.8%) vs. 3.0-T (84.1%, p=0.002).
False-negative rates were lower for 1.5-T (0.6%) compared to 3.0-T (6.1%).

Conclusions:

1.5-T DWI is more effective than 3.0-T DWI for imaging hyperacute ischemic stroke within the thrombolysis window.
Despite higher SNR/CNR at 3.0 T, lower DWI contrast impacts diagnostic performance.
Expert readers confirmed the superiority of 1.5-T DWI in this critical diagnostic scenario.