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Related Experiment Video

Updated: Jun 13, 2026

Modifying Levels of Maternal Dietary Folic Acid or Choline to Study the Impact of Deficiencies on Offspring Health Outcomes
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Published on: June 28, 2024

Maternal vitamin A supplementation and lung function in offspring.

William Checkley1, Keith P West, Robert A Wise

  • 1Division of Pulmonary and Critical Care, School of Medicine, Johns Hopkins University, Baltimore, MD 21205, USA. wcheckl1@jhmi.edu

The New England Journal of Medicine
|May 14, 2010
PubMed
Summary

Maternal vitamin A supplementation improved offspring lung function in a chronically undernourished population. This intervention led to significant increases in forced expiratory volume and forced vital capacity in preadolescent children.

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Area of Science:

  • Nutritional science
  • Pediatric pulmonology
  • Public health

Background:

  • Vitamin A is crucial for early lung development and alveolar formation.
  • Maternal vitamin A status significantly impacts offspring lung health.
  • Vitamin A deficiency during pregnancy can lead to lasting adverse effects on children's lungs.

Purpose of the Study:

  • To investigate the long-term effects of maternal vitamin A or beta-carotene supplementation on offspring lung function.
  • To assess the impact of maternal nutrient repletion in a population with chronic vitamin A deficiency.

Main Methods:

  • A cohort of 9- to 13-year-old Nepali children was studied.
  • Mothers had participated in a placebo-controlled trial of vitamin A or beta-carotene supplementation.
  • Spirometry was performed on children to measure lung function (FEV(1) and FVC).

Main Results:

  • Children whose mothers received vitamin A supplementation showed significantly higher FEV(1) and FVC.
  • Vitamin A supplementation resulted in 46 ml higher FEV(1) and 46 ml higher FVC compared to placebo.
  • Beta-carotene supplementation did not yield significant improvements in offspring lung function compared to placebo.

Conclusions:

  • Maternal vitamin A repletion improved preadolescent offspring lung function in a chronically undernourished population.
  • This intervention demonstrates a significant public health benefit for lung health.
  • Supplementation with vitamin A before, during, and after pregnancy is recommended for improved child lung development.