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Related Concept Videos

Gene Therapy00:59

Gene Therapy

Gene therapy is a technique where a gene is inserted into a person’s cells to prevent or treat a serious disease. The added gene may be a healthy version of the gene that is mutated in the patient, or it could be a different gene that inactivates or compensates for the patient’s disease-causing gene. For example, in patients with severe combined immunodeficiency (SCID) due to a mutation in the gene for the enzyme adenosine deaminase, a functioning version of the gene can be inserted. The...
Gene Therapy00:59

Gene Therapy

Gene therapy is a technique where a gene is inserted into a person’s cells to prevent or treat a serious disease. The added gene may be a healthy version of the gene that is mutated in the patient, or it could be a different gene that inactivates or compensates for the patient’s disease-causing gene. For example, in patients with severe combined immunodeficiency (SCID) due to a mutation in the gene for the enzyme adenosine deaminase, a functioning version of the gene can be inserted. The...
Targeted Cancer Therapies02:57

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against specific...
Targeted Cancer Therapies02:57

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against specific...
Combination Therapies and Personalized Medicine02:50

Combination Therapies and Personalized Medicine

Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
Cancer Vaccines01:30

Cancer Vaccines

Cancer treatment vaccines are a rapidly evolving field that offers a promising approach to immunotherapy. Unlike traditional vaccines that prevent diseases, cancer treatment vaccines are designed to treat existing cancers by stimulating the immune system to recognize and attack cancer cells.
Cancer vaccines come in two categories: preventive (prophylactic) and treatment (active). Preventive vaccines, such as the Human Papillomavirus (HPV) vaccine, protect against viruses that cause certain...

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Related Experiment Video

Updated: Jun 13, 2026

Virus Delivery of CRISPR Guides to the Murine Prostate for Gene Alteration
06:21

Virus Delivery of CRISPR Guides to the Murine Prostate for Gene Alteration

Published on: April 27, 2018

Gene therapy for prostate cancer.

Mark Tangney1, Sarfraz Ahmad, Sara A Collins

  • 1Cork Cancer Research Centre, Mercy University Hospital, Cork, Ireland. m.tangney@ucc.ie

Postgraduate Medicine
|May 14, 2010
PubMed
Summary

Gene therapy offers a promising alternative for treating prostate cancer, especially when conventional methods fail. Research shows its potential to directly target cancer cells or boost the immune system for effective tumor destruction.

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Area of Science:

  • Oncology
  • Genetics
  • Urological Malignancies

Background:

  • Cancer is a major cause of death, with prostate cancer being the most common in men.
  • Increasing life expectancy leads to higher incidence and mortality of prostate cancer.
  • Current treatments for advanced prostate cancer are often limited by toxicity and efficacy.

Purpose of the Study:

  • To explore gene therapy as a potential alternative treatment for prostate cancer.
  • To review research strategies for prostate cancer gene therapy.
  • To assess the clinical potential of gene therapy in urological malignancy treatment.

Main Methods:

  • Review of preclinical and clinical research on gene therapy for prostate cancer.
  • Analysis of various gene delivery strategies.
  • Evaluation of therapeutic mechanisms including direct cytotoxicity, immune system upregulation, and anti-angiogenesis.

Main Results:

  • Gene therapy involves delivering genetic information to produce therapeutic proteins.
  • Therapeutic proteins can induce tumor cell death, enhance immune response, or target tumor vasculature.
  • Significant research over 20 years has yielded promising preclinical and clinical results.

Conclusions:

  • Gene therapy is a realistic prospect for treating prostate and other cancers.
  • Technological advancements in gene delivery are crucial for safe and efficient gene medicine.
  • Gene therapy approaches show therapeutic efficacy and are expected to be part of future urological cancer treatment.