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Updated: Jun 13, 2026

Granulocyte-dependent Autoantibody-induced Skin Blistering
Published on: October 12, 2012
Cross-talk between hemidesmosomes and focal contacts: understanding subepidermal blistering diseases
1Kizawa Memorial Hospital, 590 Shimokobi, Kobi-cho, Minokamo City, Gifu, Japan. yaskitaj@gifu-u.ac.jp
Abstract:
Because hemidesmosomes and focal contacts (FCs) play major roles in epidermal wound healing and in the pathogenesis of subepidermal blistering diseases, it is of particular importance to understand their cross-talk in the regulation of their assembly and disassembly. In this issue, Ozawa et al. demonstrate that hemidesmosome-enriched protein complex (HPC) and FC dynamics are tightly coregulated in keratinocytes undergoing migration by employing HaCat cells that express fluorescent protein-tagged beta4 integrin and alpha-actinin as markers of HPCs and FCs.
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