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Related Experiment Video

Updated: Jun 13, 2026

ScanLag: High-throughput Quantification of Colony Growth and Lag Time
07:47

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Published on: July 15, 2014

Bistability and bacterial infections.

Roy Malka1, Eliezer Shochat, Vered Rom-Kedar

  • 1Department of Computer Science and Applied Mathematics, The Weizmann Institute of Science, Rehovot, Israel.

Plos One
|May 14, 2010
PubMed
Summary
This summary is machine-generated.

Mathematical modeling reveals two bacterial dynamics types under fixed neutrophil levels. Type II bistable dynamics, unlike Type I monostable dynamics, can explain fulminant bacterial infections and fits Staphylococcus epidermidis data.

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Area of Science:

  • Microbiology
  • Mathematical Biology
  • Immunology

Background:

  • Bacterial infections overwhelm host defenses when neutrophil count or function is low.
  • Neutrophil levels typically increase during infection but remain constant in neutropenic patients or ex vivo assays.
  • Understanding bacterial population dynamics under fixed neutrophil levels is crucial for infection control.

Purpose of the Study:

  • To investigate bacterial population dynamics under constant neutrophil levels using mathematical modeling.
  • To differentiate between monostable (Type I) and bistable (Type II) bacterial behaviors.
  • To assess the plausibility of Type II dynamics in explaining severe bacterial infections.

Main Methods:

  • Developed a mathematical model to simulate bacterial population dynamics.
  • Analyzed model outcomes under fixed neutrophil concentrations.
  • Compared model predictions with existing in vitro data for Staphylococcus epidermidis.

Main Results:

  • Identified two bacterial dynamics scenarios: Type I (monostable) and Type II (bistable).
  • Type II dynamics exhibit bistability within certain neutrophil level ranges, leading to either a healthy state or fulminant infection.
  • In vitro data for Staphylococcus epidermidis were inconsistent with Type I dynamics and linear models but consistent with Type II dynamics.

Conclusions:

  • Bacterial dynamics can be either monostable (Type I) or bistable (Type II) under fixed neutrophil levels.
  • Type II bistable dynamics provide a plausible mechanism for the development of fulminant bacterial infections.
  • This model offers new insights into host-pathogen interactions and infection severity.